Oral administration of Lactobacillus plantarum CJLP133 and CJLP243 alleviates birch pollen‐induced allergic rhinitis in mice
2018
Choi, S.‐P. | Oh, H.‐N. | Choi, C.‐Y. | Ahn, H. | Yun, H.S. | Chung, Y.M. | Kim, B. | Lee, S.J. | Chun, T.
AIMS: In this study, we evaluated the therapeutic efficacy of selected probiotics in a mouse model of birch pollen (BP)‐induced allergic rhinitis. METHODS AND RESULTS: Oral administration of Lactobacillus plantarum CJLP133 and CJLP243 ameliorated the symptoms of BP‐induced allergic rhinitis by reducing airway hyperresponsiveness, and both the histological scores and the number of infiltrated cells in the nasal cavities and lungs. Compared with those from vehicle‐treated mice, bronchoalveolar lavage fluid and draining lymph node samples from CJLP133 and CJLP243‐administrated mice showed diminished numbers of immune cells, increased secretion of a Th1‐type cytokine (IFN‐γ) and decreased production of Th2‐type cytokines (IL‐4, IL‐5 and IL‐13). Consistent with these results, levels of IL‐4, IL‐5, IL‐13, serum IgE and BP‐specific serum IgG1 were decreased, whereas secretion of IFN‐γ and BP‐specific serum IgG2a was augmented upon administration of CJLP133 and CJLP243 in mice. CONCLUSION: Oral administration of L. plantarum CJLP133 and CJLP243 alleviates symptoms of BP‐induced allergic rhinitis in mice by recovering Th1/Th2 balance via enhancement of the Th1‐type immune response. SIGNIFICANCE AND IMPACT OF THE STUDY: Lactobacillus plantarum CJLP133 and CJLP243 have therapeutic effects on BP‐induced allergic rhinitis in an animal model.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
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