In(OTf)₃ catalysed an expeditious synthesis of β-carboline–imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrazine conjugates
2016
Devi, Nisha | Singh, Dharmender | Honey, | Mor, Satbir | Chaudhary, Sandeep | Rawal, Ravindra K. | Kumar, Vipin | Chowdhury, Asim K. | Siṃha, Virendra
β-Carboline containing alkaloids are ubiquitously present in Nature, while imidazo[1,2-a]pyridine nucleus is incorporated in various synthetic commercial drugs and biologically previliged moieties. On this basis, new β-carboline–imidazoazine conjugates were designed and a small library of compounds integrating both the pharmacophores was constructed with 4-points of diversity by using the In(OTf)₃ assisted Groebke–Blackburn–Bienayme multicomponent strategy. The methodology was found to be simple and convenient for the efficient syntheses of β-carboline–imidazo[1,2-a]azine conjugates. The present synthetic protocol provides several advantages like operational simplicity, appreciable atom economy, short reaction time and easy purification procedure.
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