Biosynthesis of the azoxycarboxamide lyophyllin and formation of some of its unnatural analogues in fruit-bodies of Lyophyllum connatum

Ye, Y.; Aulinger, K.; Arnold, N.; Spahl, W.; Steglich, W.

Biosynthesis of the azoxycarboxamide lyophyllin and formation of some of its unnatural analogues in fruit-bodies of Lyophyllum connatum

1997

Ye, Y. | Aulinger, K. | Arnold, N. | Spahl, W. | Steglich, W.

The azoxy compound lyophyllin (3) is formed in fruit-bodies of the toadstool Lyophyllum connatum by oxidative condensation of N-hydroxy-N',N'-dimethylurea (2) with N-methylhydroxylamine (4). The condensing enzyme is remarkably unspecific and transforms a variety of hydroxyureas and N-alkyl-hydroxylamines into the corresponding lyophyllin analogues 5.

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