Polysaccharide-based nanocapsules for controlled release of indomethacin
2017
Kamburova, Kamelia | Mitarova, Karina | Radeva, Tsetska
Indomethacin (IMC) nanoparticles are encapsulated through layer-by-layer self-assembly of natural polysaccharides chitosan (CHI) and pectin (PEC). The adsorption of both polymers is realized in aqueous solutions containing 10⁻²M NaCl and pH 4.5, where the drug particles are practically insoluble. The stoichiometry of charges and the thickness of the polymer coating on the IMC particles, as well as the stability of their suspensions, are identified using electric light scattering. We found linear increase in the coating thickness with the number of deposited layers. Correspondingly, the electric light scattering is found to increase with increasing number of the layers, showing small excess of positive charges when the coating is terminated with the more highly charged CHI. The release rate of IMC from the nanocapsules is monitored with UV-absorbance in buffer at close to physiological pH 7, when the solubility of IMC increases several times. We found that the encapsulation of the IMC nanoparticles prolong the release time of the drug to about 5h. The released amount of IMC is also found to depend on the concentration of NaCl in the dipping polysaccharide solutions.
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