RETRACTED: High protein diet improves the overall survival in older adults with advanced gastrointestinal cancer

Pimentel, Gustavo D.; Pichard, C.; Laviano, Alessandro; Fernandes, Renata C.

RETRACTED: High protein diet improves the overall survival in older adults with advanced gastrointestinal cancer

2021

Pimentel, Gustavo D. | Pichard, C. (Claude) | Laviano, Alessandro | Fernandes, Renata C.

High protein diet (HDP) promotes improvement of lean body mass in elderly without cancer; but the impact of high protein intake on muscle strength and mortality in cancer patients remains to be elucidated. This study evaluates the association between HPD on handgrip strength (HGS) and survival in older adults outpatients with advanced gastrointestinal cancer.Ninety-one patients with advanced gastrointestinal cancer (>65% tumor stage III-IV) undergoing radiotherapy, chemotherapy or surgery were enrolled. Upon first oncological visit, tumor stage was assessed by a physician. Then, a nutritionist or a dietitian measured the body mass index (BMI), HGS by means of a dynamometer, and dietary food intake by using 24h food recall. Patients were stratified in HPD (i.e, ≥1.5 g/kg/d) or low protein diet (LPD: <1.5 g/kg/d). Kaplan–Meier curve was used to assess the survival since the cancer diagnosis.HPD was reported by approximately 30% of patients. Protein intake was significantly higher in HPD vs LPD patients (2.2 ± 0.8 vs. 0.8 ± 0.4 g/kg/d, respectively; p < 0.0001). No significant association was found between HPD and HGS, even after adjustment for physical activity, alcohol intake, smoking, sex, age, tumor stage, oncologic treatment and BMI (OR: 0.97 [95%CI: 0.88–1.08], p = 0.64), or for energy intake kcal/kg/day, leucine g/d and lipids g/d (OR: 0.93 [95%CI: 0.85–1.03, p = 0.19]. In addition, HPD group showed higher overall survival than LPD group (HPD: 14.7 vs. LPD: 7.3 months, p = 0.04).HPD is not associated with better muscle function as measured by HGS, but with overall survival in older adults outpatients with advanced gastrointestinal cancer. HPD may represent a strategy to mitigate the cancer-induced mortality and should be further explored.

اظهر المزيد [+]

الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)

age body mass index cancer clinical nutrition drug therapy elderly food intake gastrointestinal system lean body mass leucine lipids mortality muscles patients physical activity radiotherapy survival

المعلومات البيبليوغرافية

نُشرت في

Clinical nutrition

المجلد 40 الإصدار 3 ترقيم الصفحات 1376 - 1380 الرقم التسلسلي المعياري الدولي (ردمد) 0261-5614

الناشر

Elsevier Ltd

مواضيع أخرى

Gastrointestinal; Energy intake; Alcohol drinking; Low protein diet; Protein intake; Gastrointestinal neoplasms; High protein diet; Muscle strength; Surgery; Dietitians; High protein diet; Older

اللغة

إنجليزي

ملاحظة

Retracted: March 2021, v.40(3), pp.1376-1380; 10.1016/j.clnu.2020.08.028 This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editors after the authors informed them of substantive errors in the reported methods, results and conclusions that affect the reliability of the results. The authors have provided the following statement regarding the retraction of the paper: In reference to the paper above, and as a consequence of internal discussion and advice from external colleagues, we noticed that our results, which we confirm as original, could be misleading to the international scientific and clinical community. We agree that the title should have reflected more the heterogeneity of the patients. More importantly, we should have better clarified and highlighted the specific methodology used. In particular, the single dietary recall from which we derived calorie and protein intake was collected at different time points in the clinical journey of patients with cancer, either before or after anti-cancer therapies. We acknowledge that this methodology could have influenced the cancer outcomes, but a subgroup analysis would have resulted in limited statistical robustness. In the manuscript, we mention that some of the patients were receiving supplements to increase energy and protein intake. We acknowledge that protein intake is protein intake, independently from the source, but again a subgroup analysis was limited by the low number of patients enrolled. We also acknowledge the mistyping of the first sentence of the Results section, i.e. n=27 is the correct figure and not n=30. We apologize for the poor presentation of methods and results, whereas we confirm that data are original and true.

النوع

Journal Article; Text

في أجريس منذ: 2024-02-28

نوع الملف: MODS

مزود البيانات

تم تزويد هذا السجل من قبل National Agricultural Library

اكتشف مجموعة مزود البيانات هذا في أجريس

الروابط

DOI DOI http://dx.doi.org/10.1016/j.clnu.2020.08.028

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RETRACTED: High protein diet improves the overall survival in older adults with advanced gastrointestinal cancer

2021

الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)

المعلومات البيبليوغرافية