Pyruvate metabolism in BHE/cdb rats is altered by the type of dietary fat
1997
Wickwire, K. | Berdanier, C.D.
The effect of feeding corn oil (CO), hydrogenated coconut oil (HCO), or menhaden oil (MO) on hepatic pyruvate metabolism of diabetes-prone BHE/cdb rats was studied. Pyruvate-related metabolites in frozen clamped livers as well as pyruvate related enzyme activities were determined after 7 weeks of feeding. Small differences in feed efficiency were noted, as were small differences in metabolites and several key reactions. The difference in metabolism was greatest between the MO rats and the other two groups. The CO and HCO rats were similar in many respects. Lactate levels were increased in CO and HCO rats compared to MO rats. Membrane-bound lactate dehydrogenase (LDH) activities were different in the three groups of rats. Rats fed MO had lower lactate levels, but their LDH activity was greatly increased. Pyruvate levels were similar in all groups, but pyruvate carboxylase and pyruvate kinase were less active in the MO-fed rats than in the other diet groups. These findings suggest that a diet fat gene interaction has occurred that accommodates the mutation reported previously in the mitochondrial genome for F0ATPase such that the type of diet fat can potentiate or suppress the genetically determined metabolic features that characterize the BHE/cdb rat.
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