Preparation, antimicrobial and release behaviors of nisin-poly (vinyl alcohol)/wheat gluten/ZrO2 nanofibrous membranes
2015
Wang, Hualin | She, Yi | Chu, Chengjiang | Liu, Huan | Jiang, Suwei | Sun, Min | Jiang, Shaotong
A novel nisin-loaded poly (vinyl alcohol)/wheat gluten/zirconia (Nisin-PVA/WG/ZrO₂) nanofibrous membranes was prepared via electrospinning technique. The drug carrier PVA/WG/ZrO₂nanofibers showed a increase in average diameter with the increase of ZrO₂content, and the fibers tended to conglutinate when ZrO₂content reached 12 wt% and above. Hydrogen and Zr–O–C bonds existed among PVA, WG, and ZrO₂units improved the thermal stability of polymeric matrix. The loading dosage of nisin caused no significant changes in the size and morphology of nanofibers at nisin content below 6 wt%. The antimicrobial activity and release experimental results showed that the nisin-PVA/WG/ZrO₂nanofibrous membranes displayed well-controlled release and better antimicrobial activity against Staphylococcus aureus, and the nisin release from the nanofibers could be described by Fickian diffusion model. In our opinions, these nisin-PVA/WG/ZrO₂nanofibrous membranes may have potential as a new nanofibrous membrane in drug delivery, wound dressing, and active food packaging.
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