Two generation reproduction and teratogenicity studies of feeding cyadox in Wistar rats
2011
Wang, Xu | Fang, Gui-Jie | Wang, Yu-Lian | Ihsan, Awais | Huang, Ling-Li | Zhou, Wen | Liu, Zhen-Li | Yuan, Zong-Hui
To investigate the teratogenic potential and reproductive toxicity of cyadox, a growth promoting agent, Wistar rats (F₀) were fed with diets containing cyadox (0, 50, 150 and 2500mg/kg) or olaquindox (150mg/kg), approximately equivalent to cyadox 5, 15, 250 or olaquindox 15mg/kgb.w./day across two generations. Half of the pregnant rats (F₀, F₁b) were subjected to caesarean section on gestational day 20 for teratogenic examination and the other half produced pups F₁ₐ and F₂ₐ, respectively. At the 250mg/kgb.w./day cyadox group, body weights of F₁b pregnant rats and F₂ₐ on day 21 after birth decreased; fetal body lengths and tail lengths decreased; the number of fetal resorptions increased significantly; litter weights, number of viable fetuses decreased; number of embryo resorptions increased significantly; number of liveborn F₁ₐ, F₁b and F₂ₐ decreased. No macroscopic or microscopic change of any significance was found in the reproductive organs. Significant increases in the incidence of cervial ribs or lumbar ribs in F₂ₐ pups and significant increases of relative organ weight of testis and epididymis in F₁b were observed at the 250mg/kgb.w./day cyadox group. The NOAEL for reproduction/development of cyadox for rats was estimated to be 150mg/kg diet, which was equivalent to approximately 15mg/kgb.w./day.
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