Effect of Nitrate Adaptation on the Bactericidal Activity of an Experimental Chlorate Product Against Escherichia coli in Cattle
2005
Fox, J.T. | Anderson, R.C. | Carstens, G.E. | Miller, R.K. | Jung, Y.S. | McReynolds, J.L. | Callaway, T.R. | Edrington, T.S. | Nisbet, D.J.
An experimental chlorate product (ECP) developed by the United States Department of Agriculture has been shown to have bactericidal effects against enteropathogens such as Escherichia coli. In studies with broilers and pigs, the bactericidal activity of ECP was enhanced by prior adaptation of gastrointestinal microflora to nitrate. The objective of this study was to examine the effects of nitrate adaptation on the bactericidal activity of ECP against E. coli in Holstein steers. Results indicate that ECP was effective at reducing E. coli. However, ECP did not reduce E. coli in a dose-dependent manner, indicating that the highest ECP dose provided in this study exceeded that needed to be efficacious. Adapting gastrointestinal microflora with nitrate prior to feeding ECP did not improve efficacy of ECP against E. coli. Rapid reduction of nitrate in the rumen is implicated as a possible explanation for why adaptation to nitrate did not enhance the bactericidal effects of ECP in cattle.
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