Plants of the genus Vitis: Phenolic compounds, anticancer properties and clinical relevance
2019
Salehi, Bahare | Vlaisavljević, Sanja | Adetunji, Charles Oluwaseun | Adetunji, Juliana Bunmi | Kregiel, Dorota | Antolak, Hubert | Pawlikowska, Ewelina | Uprety, Yadav | Mileski, Ksenija S. | Devkota, Hari Prasad | Sharifi-Rad, Javad | Das, Gitishree | Patra, Jayanta Kumar | Jugran, Arun Kumar | Segura-Carretero, Antonio | Contreras, María del Mar
Vitis genus comprised about 70 species. Concerning its pharmacological properties, V. vinifera is the most studied one, but there are other species with interest.Therefore, this review aims to provide an updated overview on bioactive phytochemicals present in food products (grapes and wine) of V. vinifera and other Vitis species, as well as in different underused bioresources (stem, leaves, seeds, wine pomace, etc.). Moreover, due to their promising perspectives in the field of anticancer drug discovery, this bioactivity has been covered as well as the contribution that Vitis phenolic compounds has.Among the plant products reviewed, grape seed extracts was the most investigated at preclinical phase, hence exhibiting a promising potential as anticancer drugs. However, an evidence-based clinical efficacy is still lacking.
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