A database for inventory of proteoform profiles: “2DE‐pattern”
2020
Naryzhny, Stanislav | Klopov, Nikolay | Ronzhina, Natalia | Zorina, Elena | Zgoda, Victor | Kleyst, Olga | Belyakova, Natalia | Legina, Olga
The human proteome is composed of a diverse and heterogeneous range of gene products/proteoforms/protein species. Because of the growing amount of information about proteoforms generated by different methods, we need a convenient approach to make an inventory of the data. Here, we present a database of proteoforms that is based on information obtained by separation of proteoforms using 2DE followed by shotgun ESI–LC–MS/MS. The database's principles and structure are described. The database is called “2DE‐pattern” as it contains multiple isoform‐centric patterns of proteoforms separated according to 2DE principles. The database can be freely used at http://2de-pattern.pnpi.nrcki.ru.
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