The solubility of calcium from antacid tablets, calcium supplements and fortified food products
1991
Schnepf, M. | Madrick, T.
The purpose of this study was to compare calcium solubility in Tums, Rolaids, Oscal, Caltrate, fortified yogurt, and fortified orange juice. The antacids and supplements containing either 200, 400, 800, or 1600 mg of calcium were subjected to three gastric treatments in an in vitro digestion procedure which was designed to observe the influence of acid secretion on calcium solubility. The gastric pHs included normal (pH 1.5), reduced acid (pH 1.7) and achlorhydria (pH 7.2). Normal and reduced acid conditions solubilized between 83 and 98% of the total calcium with no differences (p greater than or equal to 0.05) observed among the various sources of calcium. Negligible quantities were dissolved in the achlorhydric solution. When analyzing the amount of calcium available at the four different levels and combining the sources, only 60% of 1600 mg of calcium was solubilized in the reduced acid solution compared to 87-96% solubilized at the lower levels. Fortified orange juice and yogurt samples were found to contain significant amounts of available calcium at all gastric pHs including achlorhydria. A low pH is necessary to solubilize calcium carbonate especially when higher levels of calcium are present in a single dose.
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