Pharmacological effects of Dai-saiko-to on lipid biosynthesis in cultured human hepatocyte HepG2 cells
1995
Yamamoto, K. | Ogawa, Y. | Yanagita, Y. | Morito, F. | Fukushima, N. | Ozaki, I. | Mizuta, T. | Setoguchi, Y. | Sakai, T.
The pharmacological effects of Dai-saiko-to, a Japanese and Chinese traditional medicinal mixture (Kampohozai), on lipid biosynthesis were investigated in cultured human hepatocyte HepG2 cells. The addition of Dai-saiko-to (0.5 microgram/milliliter), which had no significant effect on cell proliferation, caused a marked decrease in the intracellular triglyceride content with no significant changes in the other lipid fraction. At the same time, the incorporation of 14C-acetate or 3H-glycerol into the triglyceride or diglyceride fractions also decreased significantly. These results suggest that Dai-saiko-to decreases hepatic triglyceride biosynthesis, which might contribute to a reduction in plasma VLDL levels.
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