An olive polyphenol-based nutraceutical improves cutaneous manifestations of psoriasis in humans
2016
Herrera Acosta, E. | Alonso Suárez Pérez, J. | Aguilera Arjona, J. | Visioli, F.
Psoriasis is a chronic inflammatory disorder whose most conventional treatment includes topical agents such as corticosteroids and vitamin D analogs, phototherapy, and systemic treatments aimed at slowing down cell cycle, namely keratinocyte proliferation. Indeed, there is further need for effective yet safe remedies. We undertook a pilot, randomized, placebo-controlled, double-blind trial to evaluate the efficacy of novel olive (poly)phenol-based nutraceutical/cosmeceutical, augmented with vitamin A, riboflavin, and biotin. We recruited 30 psoriatic (mild or moderate) patients (62.5% females and 37.5% males), of which 15 were randomly allocated to a nutraceutical named Alyvium® (which contains 500mg of an olive polyphenolic extract, 200μg vitamin A, 0.35mg riboflavin, and 12.5μg of biotin per capsule; two capsules/day) and 15 patients to the placebo, i.e. two capsules/day of maltodextrins, for 12 weeks. After four weeks of treatment, the Psoriasis Area and Severity Index significantly decreased to 2.92±1.52 (−27%) in those who received the supplement and to 3±2.24 (−11%) in those who were administered the placebo. The amount of Body Surface Area affected also decreased. In conclusion, we provide the first evidence that a cosmeceutical/nutraceutical formulation based on olive (poly)phenols improve the cutaneous manifestations of psoriasis in patients who are moderately affected by this pathology. The use of supplements as adjuvant therapy of psoriasis could be anticipated.
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