Copper-Catalyzed Amination of C(sp³)–H bonds: From Anilides to Indolines
2019
Long, Jinguo | Le, Liyuan | Iwasaki, Takanori | Qiu, Renhua | Kambe, Nobuaki
Copper-catalyzed oxidative intramolecular cyclization of o-alkylated anilines via cleavage of C(sp³)–H and N–H bonds for the production of indolines is described. This approach provides a straightforward strategy for the synthesis of nitrogen-containing heterocyclic compounds through the functionalization of unactivated C(sp³)–H bonds with high site selectivity. The present catalytic system shows high preference for functionalization of unactivated C(sp³)–H bonds over C(sp²)–H bonds, leading to C–N bond formation.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
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