Automatic and Simple Method for 99Tc Determination Using a Selective Resin and Liquid Scintillation Detection Applied to Urine Samples
2013
Villar, Marina | Avivar, Jessica | Ferrer, Laura | Galmés, Margalida | Vega, Fernando | Cerdá, Victor
⁹⁹ᵐTc (6.0067 h half-life) is an artificial radionuclide largely used in diagnostic medicine. Its daughter ⁹⁹Tc is a beta emitter of great concern because of its long half-life (2.111 × 10⁵ years) and presumed mobile behavior in the environment. To monitor the ⁹⁹Tc in urine from treated patients, an automatic Lab-on-valve (LOV) system for separation and preconcentration of ⁹⁹Tc was developed. TEVA resin was selected since it retains pertechnetate ion selectively from diluted nitric acid solutions. After elution, ⁹⁹Tc is detected using a liquid scintillation counting (LSC) detector. The present method has been successfully applied to urine samples with low ⁹⁹Tc content (recoveries between 94–111%). The minimum detectable activity (MDA) of the developed method is 0.1 Bq or 1 Bq L–¹ (expressed as activity concentration), when preconcentrating 100 mL of sample. The high durability of the resin, together with the low amount of resin required (32 mg), the good reproducibility (RSD 2%, n = 5) and the high extraction frequency (up to 12 h–¹) makes of the present method an inexpensive, precise and fast useful tool for monitoring ⁹⁹Tc in urine samples.
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