In vitro antioxidant, antibacterial, and antihyperlipidemic potential of ethanolic Avicennia marina leaves extract supported by metabolic profiling
2021
Yassien, Eman E. | Hamed, Moaz M. | Abdelmohsen, Usama Ramadan | Hassan, Hanaa M. | Gazwi, Hanaa S. S.
This study aimed to examine the impact of ethanolic Avicennia marina (A. marina) leaves extract against seven pathogenic bacteria and the protective effect of this plant against hyperlipidemia caused by dexamethasone (DEX)-treated rats. Forty-eight male rats weighing between 150 and 200 g were randomly selected into six groups containing eight rats in each group. Moreover, in vitro antioxidant DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) free radical scavenging activity, FRAP (ferric reducing antioxidant power), and ABTS assay were also analyzed for leaf extract. Results showed that the IC₅₀ values were observed as 193.9 ± 1.03 μg/mL, 340.29 ± 8.16 μM TE/mg, and 326.8 ± 6.14 μM TE/mg for DPPH, FRAP, and ABTS radical scavenging activities, respectively. A. marina leaves ethanolic extract exhibited higher activity against Candida albicans and Bacillus subtilis, moderate activity against Salmonella typhimurium, and Vibrio damsel. The administration of DEX resulted in significant (P < 0.05) increase in the levels of MDA concentration, TG, TC, LDL, LDH, and glucose but decreased significantly in HDL. Treatment with A. marina extract positively reversed the distorted lipid profile and peroxidation and improved MDA, GSH, NO, and SOD activities in DEX-administered rats. Histological investigation of liver tissue sections showed that the treatment with A. marina leaves extract moderate the fatty change caused by DEX. It is concluded that A. marina leaves extract improved the hypolipidemic property of DEX administration in comparison with standard treatment with atorvastatin.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
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