Ultrastructural demonstration of mitochondrial calcium overload in myocardial cells from broiler chickens with ascites and induced hypoxia
1993
Maxwell, M.H. | Robertson, G.W. | Mitchell, M.A.
Two groups of young broiler chickens, namely, naturally occurring field cases of ascites and those with an induced hypoxia, were used in an ultrastructural study to examine the localisation and distribution of intracellular Ca2+ in cardiomyocytes. Age-matched healthy flockmates were used to control each group. Deposits of Ca2+ were located extensively in the mitochondria, sarcoplasmic reticulum and Golgi apparatus and sometimes in the myocyte and endothelial cell nuclei of both groups of birds. The results suggest that the cells from the hearts of the ascitic broilers may have been exposed to hypoxia since a large proportion of control material showed no Ca2+ activity in either mitochondria or nuclei. The presence of a Ca2+ overload in the mitochondria of cardiomyocytes from ascitic birds reared at low altitude or sea level suggests that these broilers were suffering from the deleterious effects of chronic hypoxia due to poor or reduced oxygen use.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
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