Dimethoate induces genotoxicity as a result of oxidative stress: in vivo and in vitro studies

Silva, Marcelo Souza; De Souza, Daniel Vitor; Alpire, Maria Esther Suarez; Malinverni, Andrea Cristina De Moraes; Da Silva, Regina Claudia Barbosa; Viana, Milena De Barros; Oshima, Celina Tizuko Fujiyama; Ribeiro, Daniel Araki

Dimethoate induces genotoxicity as a result of oxidative stress: in vivo and in vitro studies

2021

Dimethoate ([O,O-dimethyl S-(N-methylcarbamoylmethyl) phosphorodithioate]) is an organophosphate insecticide and acaricide widely used for agricultural purposes. Genotoxicity refers to the ability of a chemical agent interact directly to DNA or act indirectly leading to DNA damage by affecting spindle apparatus or enzymes involved in DNA replication, thereby causing mutations. Taking into consideration the importance of genotoxicity induced by dimethoate, the purpose of this manuscript was to provide a mini review regarding genotoxicity induced by dimethoate as a result of oxidative stress. The present study was conducted on studies available in MEDLINE, PUBMED, EMBASE, and Google scholar for all kind of articles (all publications published until May, 2020) using the following key words: dimethoate, omethoate, DNA damage, genetic damage, oxidative stress, genotoxicity, mutation, and mutagenicity. The results showed that many studies were published in the scientific literature; the approach was clearly demonstrated in multiple tissues and organs, but few papers were designed in humans. In summary, new studies within the field are important for better understanding the pathobiological events of genotoxicity on human cells, particularly to explain what cells and/or tissues are more sensitive to genotoxic insult induced by dimethoate.

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