Regulation of the glutamate-dependent acid-resistance system of diarrheagenic Escherichia coli strains
2003
Bhagwat, Arvind A.
The ability to withstand an acid challenge of pH 2.5 or less by Escherichia coli strains is a trait generally believed to be restricted to their stationary phase of growth. Of the three distinct acid-resistance systems that have been identified in E. coli, the glutamate-dependent acid resistance (GAD) system provides the highest level of acid resistance. Earlier reports indicated that in the exponential growth phase of E. coli K-12 strains the GAD system is not active. The present study reports that when grown on minimal medium several diarrheagenic and K-12 strains of E. coli have a complete set of induced genes necessary for GAD in the exponential growth phase to overcome the acid challenge of pH 2.5 for several hours. A previously identified factor(s) specific to the GAD system in the stationary phase and predicted to undergo dilution during the exponential phase appears to be glutamate-decarboxylase isozyme(s) inactivated differentially in the rich vs. minimal growth media.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
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