In vitro investigation of Brazilian Cerrado plant extract activity against Plasmodium falciparum, Trypanosoma cruzi and T. brucei gambiense
2016
Charneau, Sébastien | de Mesquita, Mariana Laundry | Bastos, Izabela Marques Dourado | Santana, Jaime Martins | Paula, José Elias de | Grellier, Philippe | Espindola, Laila Salmen
The threatened Brazilian Cerrado biome is an important biodiversity hotspot but still few explored that constitutes a potential reservoir of molecules to treat infectious diseases. We selected eight Cerrado plant species for screening against the erythrocytic stages of Plasmodium falciparum , human intracellular stages of Trypanosoma cruzi and bloodstream forms of T. brucei gambiense , and for their cytotoxicity upon the rat L6-myoblast cell line. Bioassays were performed with 37 hexane, ethyl acetate and ethanol extracts prepared from different plant organs. Activities against parasites were observed for 24 extracts: 9 with anti- P. falciparum , 4 with anti- T. cruzi and 11 with anti- T. brucei gambiense activities. High anti-protozoal activity (IC ₅₀ values < 10 μg/mL) without obvious cytotoxicity to L6 cells was observed for eight extracts from plants: Connarus suberosus , Blepharocalyx salicifolius , Psidium laruotteanum and Myrsine guianensis . Overall, studies of plant extracts will contribute to increase the biodiversity knowledge essential for Cerrado conservation and sustainable development.
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