Human poisoning from poisonous higher fungi: focus on analytical toxicology and case reports in forensic toxicology
2020
Flament, Estelle | Guitton, Jerome | Gaulier, Jean-Michel | Gaillard, Yvan | Laboratoire de Pharmacologie et Toxicologie ; Institut National de la Recherche Agronomique (INRA) | Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS) ; Hospices Civils de Lyon (HCL) | Impact de l'environnement chimique sur la santé humaine - ULR 4483 (IMPECS) ; Université de Lille-Centre Hospitalier Régional Universitaire [CHU Lille] (CHRU Lille) ; Université de Lille-Université de Lille
International audience
اظهر المزيد [+] اقل [-]إنجليزي. Several families of higher fungi contain mycotoxins that cause serious or even fatal poisoning when consumed by humans. The aim of this review is to inventory, from an analytical point of view, poisoning cases linked with certain significantly toxic mycotoxins: orellanine, α- and β-amanitin, muscarine, ibotenic acid and muscimol, and gyromitrin. Clinicians are calling for the cases to be documented by toxicological analysis. This document is therefore a review of poisoning cases involving these mycotoxins reported in the literature and carries out an inventory of the analytical techniques available for their identification and quantification. It seems indeed that these poisonings are only rarely documented by toxicological analysis, due mainly to a lack of analytical methods in biological matrices. There are many reasons for this issue: the numerous varieties of mushroom involved, mycotoxins with different chemical structures, a lack of knowledge about distribution and metabolism. To sum up, we are faced with (i) obstacles to the documentation and interpretation of fatal (or non-fatal) poisoning cases and (ii) a real need for analytical methods of identifying and quantifying these mycotoxins (and their metabolites) in biological matrices.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institut national de la recherche agronomique
