Impact of Foods and Dietary Supplements Containing Hydroxycinnamic Acids on Cardiometabolic Biomarkers: A Systematic Review to Explore Inter-Individual Variability
2019
Martini, D. | Chiavaroli, L. | Gonzalez-Sarrias, A. | Bresciani, L. | Palma-Duran, S. A. | Dall'Asta, M. | Deligiannidou, G. E. | Massaro, M. | Scoditti, E. | Combet, E. | Maksimova, V. | Urpi-Sarda, M. | Kontogiorgis, C. A. | Andres-Lacueva, C. | Gibney, E. R. | del Rio, D. | Morand, Christine | Garcia-Aloy, M. | Rodriguez-Mateos, A. | Mena, P. | Department of Veterinary Science ; Nippon Veterinary and Life Science University | Department of Food & Drug ; Università degli studi di Parma = University of Parma (UNIPR) | Department of Nutritional Sciences ; Mount Sinai Hospital [Toronto, Canada] (MSH) | University of Toronto | Grupo de Calidad, Seguridad y Bioactividad de Alimentos Vegetales ; Centro de Edafologia y Biologia Aplicada del Segura | College of Medical, Veterinary and Life Sciences [Glasgow] ; University of Glasgow | University of Glasgow | Department of Medicine ; Laboratory of Hygiene and Environmental Protection | Democritus University of Thrace (DUTH) | Istituto di Fisiologia Clinica (IFC), CNR | Department of Applied Pharmacy ; Faculty of Medical Sciences | University Goce Delcev (UGD) | Department of Nutrition, Food Sciences and Gastronomy ; Universitat de Barcelona (UB) | XaRTA | INSA·UB | Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERFES) | Instituto de Salud Carlos III [Madrid] (ISCIII) | UCD Institute of Food and Health | University College Dublin [Dublin] (UCD) | School of Advanced Studies on Food and Nutrition | Università degli studi di Parma = University of Parma (UNIPR) | Unité de Nutrition Humaine (UNH) ; Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]) | King‘s College London | European Cooperation in Science and Technology (COST) FA1403-POSITIVe
This article belongs to the Special Issue Plant Food, Nutrition and Human Health
اظهر المزيد [+] اقل [-]إنجليزي. Plant-based diets rich in bioactive compounds such as polyphenols have been shown to positively modulate the risk of cardiometabolic (CM) diseases. The inter-individual variability in the response to these bioactives may affect the findings. This systematic review aimed to summarize findings from existing randomized clinical trials (RCTs) evaluating the effect of hydroxycinnamic acids (HCAs) on markers of CM health in humans. Literature searches were performed in PubMed and the Web of Science. RCTs on acute and chronic supplementation of HCA-rich foods/extracts on CM biomarkers were included. Forty-four RCTs (21 acute and 23 chronic) met inclusion criteria. Comparisons were made between RCTs, including assessments based on population health status. Of the 44 RCTs, only seven performed analyses on a factor exploring inter-individual response to HCA consumption. Results demonstrated that health status is a potentially important effect modifier as RCTs with higher baseline cholesterol, blood pressure and glycaemia demonstrated greater overall effectiveness, which was also found in studies where specific subgroup analyses were performed. Thus, the effect of HCAs on CM risk factors may be greater in individuals at higher CM risk, although future studies in these populations are needed, including those on other potential determinants of inter-individual variability. PROSPERO, registration number CRD42016050790.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
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