Glycan complexity dictates microbial resource allocation in the large intestine
2015
Rogowski, Artur | Briggs, Jonathon A. | Mortimer, Jennifer C. | Tryfona, Theodora | Terrapon, Nicolas | Lowe, Elisabeth C. | Basle, Arnaud | Morland, Carl | Day, Alison M. | Zheng, Hongjun | Rogers, Theresa E. | Thompson, Paul | Hawkins, Alastair R. | Yadav, Madhav P. | Henrissat, Bernard | Martens, Eric C. | Dupree, Paul | Gilbert, Harry J. | Bolam, David N. | Newcastle University [Newcastle] | University of Cambridge [UK] (CAM) | Architecture et fonction des macromolécules biologiques (AFMB) ; Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS) | University of Michigan Medical School [Ann Arbor] ; University of Michigan [Ann Arbor] ; University of Michigan System-University of Michigan System | Eastern Regional Research Center ; USDA-ARS : Agricultural Research Service
An erratum to this article is available online at https://doi.org/10.1038/ncomms10705
اظهر المزيد [+] اقل [-]International audience
اظهر المزيد [+] اقل [-]إنجليزي. The structure of the human gut microbiota is controlled primarily through the degradation of complex dietary carbohydrates, but the extent to which carbohydrate breakdown products are shared between members of the microbiota is unclear. We show here, using xylan as a model, that sharing the breakdown products of complex carbohydrates by key members of the microbiota, such as Bacteroides ovatus, is dependent on the complexity of the target glycan. Characterization of the extensive xylan degrading apparatus expressed by B. ovatus reveals that the breakdown of the polysaccharide by the human gut microbiota is significantly more complex than previous models suggested, which were based on the deconstruction of xylans containing limited monosaccharide side chains. Our report presents a highly complex and dynamic xylan degrading apparatus that is fine-tuned to recognize the different forms of the polysaccharide presented to the human gut microbiota.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
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تم تزويد هذا السجل من قبل Institut national de la recherche agronomique