Impact of ZrO2 Content on the Formation of Sr-Enriched Phosphates in Al2O3/ZrO2 Nanocomposites for Bone Tissue Engineering.
2024
NUNES, F. C. | SANTOS, S. I. P. | COLNAGO, L. A. | HAMMER, P. | FERREIRA, J. A. | AMBRÓSIO, C. E. | PALLONE, E. M. J. A. | UNIVERSITY OF SÃO PAULO (USP); UNIVERSITY OF SÃO PAULO (USP); LUIZ ALBERTO COLNAGO, CNPDIA; SÃO PAULO STATE UNIVERSITY (UNESP); FUNDAÇÃO HERMÍNIO OMETTO (FHO); UNIVERSITY OF SÃO PAULO (USP); UNIVERSITY OF SÃO PAULO (USP).
Abstract: This study investigates the profound impact of the ZrO2 inclusion volume on the characteristics of Al2O3/ZrO2 nanocomposites, particularly influencing the formation of calcium phosphates on the surface. This research, aimed at advancing tissue engineering, prepared nanocomposites with 5, 10, and 15 vol% ZrO2 , subjecting them to chemical surface treatment for enhanced calcium phosphate deposition sites. Biomimetic coating with Sr-enriched simulated body fluid (SBF) further enhanced the bioactivity of nanocomposites. While the ZrO2 concentration heightened the oxygen availability on nanocomposite surfaces, the quantity of Sr-containing phosphate was comparatively less influenced than the formation of calcium phosphate phases. Notably, the coated nanocomposites exhibited a high cell viability and no toxicity, signifying their potential in bone tissue engineering. Overall, these findings contribute to the development of regenerative biomaterials, holding promise for enhancing bone regeneration therapies.
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