Advances in Nanotechnology for Enhanced Leukemia Therapy: A Systematic Review of In Vivo Studies
2023
Mir Hosseini, Ahmad | Dianaty, Shiva | Shahhosseini, Sara | Biglarifard, Reza | Razmi, Razieh | Komeili, Nima | Soltani, Danial
Introduction: Leukemia, a heterogeneous group of blood cancers, can present a significant clinical challenge due to its varying subtypes and complexity. The application of nanotechnology has the potential to revolutionize the treatment of leukemia. Based on in vivo studies, this systematic review provided an accurate and current assessment of nanotechnology therapeutic advances in leukemia treatment. Materials and methods: The present systematic review focused on in vivo studies investigating the therapeutic potential of nanotechnology for leukemia treatment. Comprehensive searches were conducted across significant databases, including PubMed, Scopus, and Google Scholar, to identify relevant publications. Selection criteria encompassed studies that employed animal models to assess nanotechnology effects on leukemia progression. Data extracted from selected articles were rigorously analyzed. This review included studies published between 2010 and 2022. Results: Based on the inclusion criteria, 24 relevant studies were identified. According to the findings of this review, nanotechnology has made substantial progress in the treatment of leukemia, as demonstrated by in vivo studies. Advanced nanoparticle-based drug delivery systems, precision gene therapies, and targeted therapeutic approaches have consistently exhibited superior outcomes in treating various leukemia subtypes in animal models. These compelling results emphasize the transformative potential of nanotechnology for leukemia therapy. Conclusion: In summary, the meticulous analyses of the in vivo studies underscore the role that nanotechnology plays in the advancement of the treatment of leukemia. Nanotechnology has demonstrated efficacy in preclinical models, indicating that it can be translated into clinical applications, offering new avenues for treating leukemia and reinforcing its position as an innovative therapeutic approach.
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