Cerebral Venous Thrombosis: Clinical, Radiological, Biological, and Etiological Characteristics of a French Prospective Cohort (FPCCVT)-Comparison With ISCVT Cohort
2021
Triquenot Bagan, Aude | Crassard, Isabelle | Drouet, Ludovic | Barbieux-Guillot, Marianne | Marlu, Raphael | Robinet-Borgomino, Emmanuelle | Morange, Pierre-Emmanuel | Wolff, Valerie | Grunebaum, Lelia | Klapczynski, Frederic | Andre-Kerneis, Elisabeth | Pico, Fernando | Martin-Bastenaire, Brigitte | Ellie, Emmanuel | Menard, Fanny | Rouanet, Francois | Freyburger, Genevieve | Godeneche, Gaelle | Allano, Hong-An | Moulin, Thierry | Mourey, Guillaume | Derex, Laurent | Berruyer, Micheline | Runavot, Gwenaelle | Trichet, Catherine | Viader, Fausto | Le Querrec, Agnes | Husein, Thomas Tarek | Cluet-Dennetiere, Sophie | Macian-Montoro, Francisco | Donnard, Magali | Guillon, Benoit | Ternisien, Catherine | Zuber, Mathieu | Laplanche, Sophie | Tassan, Philippe | Peeltier, Jean-Yves | Canaple, Sandrine | Roussel, Bertrand | Gaillard, Nicolas | Scavazza, Emilie | Le Cam Duchez, Veronique | CHU Rouen ; Normandie Université (NU) | Hôpital Lariboisière-Fernand-Widal [APHP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) | Centre Hospitalier Universitaire [CHU Grenoble] (CHUGA) | Centre de référence national des angiœdèmes (CREAK) ; Centre Hospitalier Universitaire [CHU Grenoble] (CHUGA)-Université Grenoble Alpes (UGA) | CHU Marseille | Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN) ; Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Hôpital de la Timone [CHU - APHM] (TIMONE) | Service de Neurologie [Strasbourg] ; Centre Hospitalier Universitaire [Strasbourg] (CHU Strasbourg) ; Hôpitaux Universitaires de Strasbourg (HUS)-Hôpitaux Universitaires de Strasbourg (HUS)-Nouvel Hôpital Civil de Strasbourg ; Hôpitaux Universitaires de Strasbourg (HUS) | Centre Hospitalier Universitaire [Strasbourg] (CHU Strasbourg) ; Hôpitaux Universitaires de Strasbourg (HUS) | Centre Hospitalier de Meaux | CHU Pitié-Salpêtrière [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) | Centre Hospitalier de la Côte Basque (CHCB) | Centre Hospitalier Universitaire de Bordeaux (CHU Bordeaux) | Etablissement Français du Sang Nouvelle Aquitaine [Bordeaux] (EFS Bordeaux Nouvelle Aquitaine) | Hôpitaux La Rochelle Ré Aunis [Groupe hospitalier littoral Atlantique] | Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon) | Health Service and Performance Research (HESPER) ; Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon | Centre hospitalier Victor Dupouy [Centre hospitalier d'Argenteuil] (CH Argenteuil) | Neuropsychologie et imagerie de la mémoire humaine (NIMH) ; Université de Caen Normandie (UNICAEN) ; Normandie Université (NU)-Normandie Université (NU)-GIP Cyceron (Cyceron) ; Université de Caen Normandie (UNICAEN) ; Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie (CHU Caen Normandie) ; Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie (CHU Caen Normandie) ; Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École Pratique des Hautes Études (EPHE) ; Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM) | CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie (CHU Caen Normandie) ; Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN) | Centre Hospitalier Compiègne-Noyon | Hôpital Dupuytren [CHU Limoges] | Service d'Hématologie biologique [CHU Limoges] ; CHU Limoges | Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes) | Centre hospitalier Saint-Joseph [Paris] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) | CHI Poissy-Saint-Germain | Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 (LNFP) ; Université de Picardie Jules Verne (UPJV) | CHU Amiens-Picardie | CHU Montpellier = Montpellier University Hospital ; Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier) | Centre Hospitalier Saint Jean de Perpignan | Université de Rouen Normandie (UNIROUEN) ; Normandie Université (NU)
International audience
اظهر المزيد [+] اقل [-]إنجليزي. Introduction:Cerebral venous thrombosis (CVT) is a rare disease with highly variable clinical presentation and outcome. Etiological assessment may be negative. The clinical and radiological presentation and evolution can be highly variable. The mechanisms involved in this variability remain unknown.Objective:The aim of this multicenter French study registered on ClinicalTrials.gov (NCT02013635) was therefore to prospectively recruit a cohort of patients with cerebral venous thrombosis (FPCCVT) in order to study thrombin generation and clot degradation, and to evaluate their influence on clinical radiological characteristics. The first part of the study was to compare our cohort with a reference cohort.Methods:This prospective, multicenter, French study was conducted from July 2011 to September 2016. Consecutive patients (aged >15 years) referred to the stroke units of 21 French centers and who had a diagnosis of symptomatic CVT were included. All patients gave their written informed consent. The diagnosis of CVT had to be confirmed by imaging. Clinical, radiological, biological, and etiological characteristics were recorded at baseline, at acute phase, at 3 months and at last follow-up visit. Thrombophilia screening and the choice of treatment were performed by the attending physician. All data were compared with data from the International Study on CVT published by Ferro et al.Results:Two hundred thirty-one patients were included: 117 (50.6%) had isolated intracranial hypertension, 96 (41.5%) had focal syndrome. During hospitalization, 229 (99.1%) patients received anticoagulant treatment. Median length of hospital stay was 10 days. Five patients died during hospitalization (2.2%). At 3 months, 216 patients (97.0%) had follow-up with neurological data based on an outpatient visit. The mean duration of antithrombotic treatment was 9 months, and the mean time to last follow-up was 10.5 months. At the end of follow-up, eight patients had died, and 26 patients were lost to follow-up. At least one risk factor was identified in 200 patients.Conclusions:We demonstrated that the FPCCVT cohort had radiological, biological, and etiological characteristics similar to the historical ISCVT cohort. Nevertheless, the initial clinical presentation was less severe in our study probably due to an improvement in diagnostic methods between the two studies.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institut national de la recherche agronomique