Adipose tissue transcriptome reflects variations between subjects with continued weight loss and subjects regaining weight 6 mo after caloric restriction independent of energy intake.
2010
Márquez-Quiñones, Adriana | Mutch, David, M. | Debard, Cyrille | Wang, Ping | Combes, Marion | Roussel, Balbine | Holst, Claus | Martinez, J Alfredo | Handjieva-Darlenska, Teodora | Kalouskova, Pavla | Jebb, Susan | Babalis, Dimitris | Pfeiffer, Andreas, F. H. | Larsen, Thomas, M. | Astrup, Arne | Saris, Wim, H. M. | Mariman, Edwin | Clément, Karine | Vidal, Hubert | Langin, Dominique | Viguerie, Nathalie | Institut de médecine moléculaire de Rangueil (I2MR) ; Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université de Toulouse (UT)- Institut Fédératif de Recherche Bio-médicale Institution (IFR150)-Institut National de la Santé et de la Recherche Médicale (INSERM) | Laboratoire de Santé Publique et Informatique Médicale (SPIM) ; Institut National de la Santé et de la Recherche Médicale (INSERM) | Department of Human Health and Nutritional Sciences ; University of Guelph [Guelf, Ontario, Canada] | Régulations métaboliques, nutrition et diabètes - UM55 (RMND UM55) ; Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon) ; Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) | Department of Human Biology ; Maastricht University [Maastricht] | Institute of Preventive Medicine ; Copenhagen University Hospitals [Copenhague] | Department of Physiology and Nutrition ; Universidad de Navarra [Pamplona] (UNAV) | Department of Pharmacology and Toxicology, Medical Faculty ; Medical University | Obesity Management Centre ; Institute of Endocrinology | Human Nutrition Research ; Elsie Widdowson Laboratory | Department of Internal Medicine ; University Hospital of Heraklion | Department of Clinical Nutrition ; Charité - UniversitätsMedizin = Berlin University Medicine | Department of Human Nutrition ; Faculty of Life Science [Copenhagen] ; University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH) | Centre de Recherche en Nutrition Humaine d'Ile-de-France (CRNH-IDF) ; Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Veille Sanitaire (INVS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Conservatoire National des Arts et Métiers [Cnam] (Cnam)-Institut National Agronomique Paris-Grignon (INA P-G)-CETAF-Institut National de la Santé et de la Recherche Médicale (INSERM) | Laboratoire de Biochimie [CHU Toulouse] ; Institut Fédératif de Biologie (IFB) ; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle Biologie [CHU Toulouse] ; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse) | European Community [FP6-513946]; Institut National de la Sante et de la Recherche Medicale; Region Midi-Pyrenees
International audience
اظهر المزيد [+] اقل [-]إنجليزي. BACKGROUND: The mechanisms underlying body weight evolution after diet-induced weight loss are poorly understood. OBJECTIVE: We aimed to identify and characterize differences in the subcutaneous adipose tissue (SAT) transcriptome of subjects with different weight changes after energy restriction-induced weight loss during 6 mo on 4 different diets. DESIGN: After an 8-wk low-calorie diet (800 kcal/d), we randomly assigned weight-reduced obese subjects from 8 European countries to receive 4 diets that differed in protein and glycemic index content. In addition to anthropometric and plasma markers, SAT biopsies were taken at the beginning [clinical investigation day (CID) 2] and end (CID3) of the weight follow-up period. Microarray analysis was used to define SAT gene expression profiles at CID2 and CID3 in 22 women with continued weight loss (successful group) and in 22 women with weight regain (unsuccessful group) across the 4 dietary arms. RESULTS: Differences in SAT gene expression patterns between successful and unsuccessful groups were mainly due to weight variations rather than to differences in dietary macronutrient content. An analysis of covariance with total energy intake as a covariate identified 1338 differentially expressed genes. Cellular growth and proliferation, cell death, cellular function, and maintenance were the main biological processes represented in SAT from subjects who regained weight. Mitochondrial oxidative phosphorylation was the major pattern associated with continued weight loss. CONCLUSIONS: The ability to control body weight loss independent of energy intake or diet composition is reflected in the SAT transcriptome. Although cell proliferation may be detrimental, a greater mitochondrial energy gene expression is suggested as being beneficial for weight control. This trial was registered at clinicaltrials.gov as NCT00390637.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institut national de la recherche agronomique