Reduced Production of Pro-Inflammatory and Pro-Catabolic Factors by Human Serum Metabolites Derived from a Patented Saffron Extract Intake
2024
Pourtau, Line | Wauquier, Fabien | Boutin-Wittrant, Line | Gaudout, David | Moras, Benjamin | Vignault, Adeline | Vaysse, Carole | Richard, Tristan | Courtois, Arnaud | Krisa, Stéphanie | Roux, Véronique | Macian, Nicolas | Pickering, Gisèle | Wittrant, Yohann | Activ'Inside | Equipe Nutrition, Santé et Biochimie des Lipides (ITERG) | Unité de Recherche Œnologie [Villenave d'Ornon] (OENO) ; Université de Bordeaux (UB)-Institut des Sciences de la Vigne et du Vin (ISVV)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | MetaboHUB-Bordeaux ; MetaboHUB | Plateforme Bordeaux Metabolome ; Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-MetaboHUB-Bordeaux ; MetaboHUB-MetaboHUB | Centre Hospitalier Universitaire de Bordeaux (CHU Bordeaux) | Centre hospitalo-universitaire, Clermont-Ferrand, Centre d'Investigation Clinique, INSERM, CIC1405, Clermont-Ferrand, France; Inserm, F-CRIN, Innovative Clinical Research Network in VACcinology (I-REIVAC), Paris, France | Centre d'Investigation Clinique [CHU Clermont-Ferrand] (CIC 1405) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Direction de la Recherche Clinique et de l’Innovation [CHU Clermont-Ferrand] (DRCI) ; CHU Clermont-Ferrand-CHU Clermont-Ferrand | Faculté de Médecine - Clermont-Auvergne (FM - UCA) ; Université Clermont Auvergne (UCA) | U 1405 ; CIC/Centre de Pharmacologie Clinique | Institut National de la Santé et de la Recherche Médicale (INSERM) | CHU Clermont-Ferrand | Unité de Nutrition Humaine (UNH) ; Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA)
International audience
اظهر المزيد [+] اقل [-]إنجليزي. Safe and anti-inflammatory plant-based natural products present an increasing focus in the treatment of chronic inflammatory diseases such as osteoarthritis or inflammatory bowel diseases. Among them, saffron, a spice derived from the stigma of Crocus sativus, could have anti-inflammatory properties and would be therefore a promising therapeutic agent for the treatment of such conditions. However, the anti-inflammatory molecular mechanisms of saffron in humans are still understudied and unclear. In this study, combining human serum metabolites and cell cultures, we evaluated the effect of circulating metabolites from the consumption of a patented saffron extract (Safr’InsideTM) on the chondrocytes and colon epithelial cell responses to inflammatory stress. Parametric or non-parametric Analysis of Variance with post hoc tests was performed. We demonstrated that human serum containing metabolites from saffron intake attenuated IL-1β-stimulated production of PGE2 and MMP-13 in chondrocyte cells and limited the increase in ICAM-1, MCP-1, iNOS, and MMP-3 in human epithelial cells following combined IL-1β and TNF-α inflammatory stimulation. Altogether, these data provide new findings into the mechanisms underlying the beneficial effects of saffron on chondrocytes and enterocyte cells at the cellular level and in the context of chronic inflammatory disorders.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institut national de la recherche agronomique