Evaluation of adaptive immune responses and heterologous protection induced by inactivated bluetongue virus vaccines
2015
Breard, Emmanuel | Belbis, Guillaume | Viarouge, Cyril | Nomikou, Kyriaki | Haegeman, Andy | de Clercq, Kris | Hudelet, Pascal | Hamers, Claude | Moreau, Francis | Lilin, Thomas | Durand, Benoit | Mertens, Peter | Vitour, Damien | Sailleau, Corinne | Zientara, Stéphan | Virologie UMR1161 (VIRO) ; École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES) | Unité de pathologie du Bétail ; École nationale vétérinaire d'Alfort (ENVA) | Pirbright Institute | Sciensano [Bruxelles] ; Pasteur Network (Réseau International des Instituts Pasteur) | Merial S.A.S. | Centre de recherche biomédicale (CRBM) ; École nationale vétérinaire d'Alfort (ENVA)-Université Paris-Est (UPE) | Unité Epidémiologie, ; Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES) | European Project: 245266,EC:FP7:KBBE,FP7-KBBE-2009-3,ORBIVAC(2010)
International audience
اظهر المزيد [+] اقل [-]إنجليزي. Eradication of bluetongue virus is possible, as has been shown in several European countries. New serotypes have emerged, however, for which there are no specific commercial vaccines. This study addressed whether heterologous vaccines would help protect against 2 serotypes. Thirty-seven sheep were randomly allocated to 7 groups of 5 or 6 animals. Four groups were vaccinated with commercial vaccines against BTV strains 2, 4, and 9. A fifth positive control group was given a vaccine against BTV-8. The other 2 groups were unvaccinated controls. Sheep were then challenged by subcutaneous injection of either BTV-16 (2 groups) or BTV-8 (5 groups). Taken together, 24/25 sheep from the 4 experimental groups developed detectable antibodies against the vaccinated viruses. Furthermore, sheep that received heterologous vaccines showed significantly reduced viraemia and clinical scores for BTV-16 when compared to unvaccinated controls. Reductions in clinical signs and viraemia among heterologously vaccinated sheep were not as common after challenge with BTV-8. This study shows that heterologous protection can occur, but that it is difficult to predict if partial or complete protection will be achieved following inactivated-BTV vaccination.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institut national de la recherche agronomique
