Transcriptional analysis of abdominal fat in chickens divergently selected on bodyweight at two ages reveals novel mechanisms controlling adiposity: validating visceral adipose tissue as a dynamic endocrine and metabolic organ.
2017
Resnyk, Christopher W. | Carré, Wilfrid | Wang, Xiaofei | Porter, Tom E. | Simon, Jean | Duval, Elisabeth | Duclos, Michel Jacques, M.J. | Aggrey, Sam E. | Cogburn, Larry A. | Department of Animal and Food Sciences ; University of Delaware [Newark] | Service de Génétique moléculaire et Génomique [CHU Rennes] ; Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] | Department of Biological Sciences ; Tennessee State University | Department of Animal and Avian Sciences ; University of Maryland [College Park] (UMD) ; University System of Maryland-University System of Maryland | Unité de Recherches Avicoles (URA) ; Institut National de la Recherche Agronomique (INRA) | Department of Poultry Science ; University of Georgia [USA] | United States Department of Agriculture, Cooperative State Research, Education, and Extension Service, Initiative for Future Agriculture and Food Systems (USDA-CREES-IFAFS), Grant 00-52100-9614;Avian Biosciences Center and the Institutional Development Award (IDeA) Network of Biomedical Research Excellence (INBRE), Core Fee Wavier Program at the University of Delaware
The present analyses of the visceral fat transcriptome in chickens divergently selected for a large difference in growth rate and abdominal fatness clearly demonstrate that abdominal fat is a very dynamic metabolic and endocrine organ in the chicken. The HG chickens overexpress many transcription factors and their direct target genes, which should enhance in situ lipogenesis and ultimately adiposity. Our observation of enhanced expression of hemostasis and endocrine-signaling genes in diminished abdominal fat of LG cockerels provides insight into genetic mechanisms involved in divergence of abdominal fatness and somatic growth in avian and perhaps mammalian species, including humans.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institut national de la recherche agronomique