A meta-analysis of genome-wide association studies identifies multiple longevity genes

Deelen, Joris | Evans, Daniel | Arking, Dan, E. | Tesi, Niccolò | Nygaard, Marianne | Liu, Xiaomin | Wojczynski, Mary | Biggs, Mary | van Der Spek, Ashley | Atzmon, Gil | Ware, Erin | Sarnowski, Chloé | Smith, Albert | Seppälä, Ilkka | Cordell, Heather, J. | Dose, Janina | Amin, Najaf | Arnold, Alice | Ayers, Kristin | Barzilai, Nir | Becker, Elizabeth | Beekman, Marian | Blanché, Hélène | Christensen, Kaare | Christiansen, Lene | Collerton, Joanna | Cubaynes, Sarah | Cummings, Steven | Davies, Karen | Debrabant, Birgit | Deleuze, Jean-François | Duncan, Rachel | Faul, Jessica | Franceschi, Claudio | Galan, Pilar | Gudnason, Vilmundur | Harris, Tamara, B. | Huisman, Martijn | Hurme, Mikko | Jagger, Carol | Jansen, Iris | Jylhä, Marja | Kähönen, Mika | Karasik, David | Kardia, Sharon | Kingston, Andrew | Kirkwood, Thomas | Launer, Lenore | Lehtimäki, Terho | Lieb, Wolfgang | Lyytikäinen, Leo-Pekka | Martin-Ruiz, Carmen | Min, Junxia | Nebel, Almut | Newman, Anne | Nie, Chao | Nohr, Ellen | Orwoll, Eric | Perls, Thomas | Province, Michael | Psaty, Bruce | Raitakari, Olli | Reinders, Marcel | Robine, Jm | Rotter, Jerome | Sebastiani, Paola | Smith, Jennifer | Sørensen, Thorkild, I. A. | Taylor, Kent, D | Uitterlinden, André, G. | van Der Flier, Wiesje | van Der Lee, Sven | van Duijn, Cornelia, M. | van Heemst, Diana | Vaupel, James | Weir, David | Ye, Kenny | Zeng, Yi | Zheng, Wanlin | Holstege, Henne | Kiel, Douglas | Lunetta, Kathryn | Slagboom, P. Eline | Murabito, Joanne | Max planck Institute for Biology of Ageing [Cologne] | Leiden University Medical Center (LUMC) ; Universiteit Leiden = Leiden University | California Pacific Medical Center Research Institute | Johns Hopkins University School of Medicine [Baltimore] | Johns Hopkins University (JHU) | Department of Neurology, Alzheimer Centre, VU Medical Centre, Amsterdam ; Department of Neurology, Alzheimer Centre, VU Medical Centre, Amsterdam | Department of Clinical Genetics (Academic Medical Center, University of Amsterdam) ; VU University Medical Center [Amsterdam] | Delft Bioinformatics Lab [Delft] ; Delft University of Technology (TU Delft) | University of Southern Denmark (SDU) | Beijing Genomics Institute [Shenzhen] (BGI) | China National GeneBank | Division of Statistical Genomics ; Washington University School of Medicine in St. Louis ; Washington University in Saint Louis (WUSTL)-Washington University in Saint Louis (WUSTL) | Department of Biostatistics ; University of Washington [Seattle] | Department of Medicine ; University of Washington [Seattle] | Department of Epidemiology [Rotterdam] ; Erasmus University Medical Center [Rotterdam] (Erasmus MC) | Department of Medicine [Bronx, NY, USA] ; Albert Einstein College of Medicine [New York] | Department of Biology, Faculty of Sciences and Science Education, Haifa University ; Ǧāmiʿat͏̈ Hayfā = University of Haifa | Institute for Social Research ; University of Michigan [Ann Arbor] ; University of Michigan System-University of Michigan System | Department of Biostatistics [Boston, MA, USA] ; Harvard T.H. Chan School of Public Health | Icelandic Heart Association [Kopavogur, Iceland] (IHA) | Department of Biostatistics ; University of Michigan [Ann Arbor] ; University of Michigan System-University of Michigan System | Department of Clinical Chemistry ; Tempere University | Institute of Genetic Medicine [Newcastle] ; Newcastle University [Newcastle] | Institute of Clinical Molecular Biology ; Christian-Albrechts-Universität zu Kiel = Christian-Albrechts University of Kiel = Université Christian-Albrechts de Kiel (CAU) | SEMA4 | Department of Biostatistics, University of Washington | Boston University [Boston] (BU) | Fondation Jean Dausset CEPH | Odense University Hospital, Odense | Copenhagen University Hospital | Institute of Health and Society ; Newcastle University [Newcastle] | Mécanismes moléculaires dans les démences neurodégénératives (MMDN) ; École Pratique des Hautes Études (EPHE) ; Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM) | Institute of Neuroscience [Newcastle] (ION) ; Newcastle University [Newcastle] | Institute of Clinical Research ; University of Southern Denmark (SDU) | Centre National de Génotypage (CNG) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA) | Institute of Health and Society ; Newcastle University [Newcastle] | Institute of Ageing and Health, Newcastle University, Newcastle Upon Tyne ; Institute of Ageing and Health, Newcastle University, Newcastle Upon Tyne | Institute for Social Research ; University of Michigan [Ann Arbor] ; University of Michigan System-University of Michigan System | Department of Applied Mathematics and Centre of Bioinformatics, ; Lobachevsky State University [Nizhni Novgorod] | Institute of Neurological Sciences of Bologna IRCCS | Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153) ; Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [Cnam] (Cnam)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)) ; Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM) | Icelandic Heart Association ; Heart Preventive Clinic and Research Institute | University of Iceland [Reykjavik] | National Institute on Aging [Bethesda, USA] (NIA) ; National Institutes of Health [Bethesda, MD, USA] (NIH) | Department of Clinical Epidemiology and Biostatistics, VU Medical Centre, Amsterdam ; Department of Clinical Epidemiology and Biostatistics, VU Medical Centre, Amsterdam | Amsterdam Public Health Research Institute [The Netherlands] | Department of Microbiology and Immunology ; University of Tampere [Finland] | Newcastle University [Newcastle] | Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne ; Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne | Institute of Health & Society ; Newcastle University [Newcastle] | Department of Complex Trait Genetics ; Vrije Universiteit Amsterdam [Amsterdam] (VU) | University of Tampere [Finland] | Tampere University Hospital | School of Public Health ; University of Michigan [Dearborn] ; University of Michigan System-University of Michigan System | Faculty of Medicine and Life Sciences [Tampere] ; University of Tampere [Finland] | Institute of Epidemiology and Biobank PopGen ; Christian-Albrechts-Universität zu Kiel = Christian-Albrechts University of Kiel = Université Christian-Albrechts de Kiel (CAU) | Faculty of Medicine and Health Technology [Tampere, Finland] ; University of Tampere [Finland] | Zhejiang University School of Medicine [China] | University of Pittsburgh Graduate School of Public Health | Oregon Health & Sciences University ; Oregon Health and Science University [Portland] (OHSU) | Boston University School of Medicine (BUSM) ; Boston University [Boston] (BU) | University of Washington [Seattle] | Department of Medicine, University of Washington | Department of Epidemiology, University of Washington | Kaiser Permanente Washington Health Research Institute [Seattle] (KPWHRI) | University of Turku | School of Medicine [Los Angeles] ; University of California [Los Angeles] (UCLA) ; University of California (UC)-University of California (UC) | UCLA Medical Center | University of Michigan [Ann Arbor] ; University of Michigan System | University of Copenhage, Faculty of Health and Medical Sciences | MRC Integrative Epidemiology Unit [Bristol, Royaume-Uni] (MRC IEU) ; University of Bristol [Bristol] | Los Angeles Biomedical Research Institute (LA BioMed) | Harbor UCLA Medical Center [Torrance, Ca.] | Netherlands Genomics Initiative ; Netherlands Consortium for Healthy Aging [Leiden, Netherlands] (NCHA) | Department of Internal Medicine (ROTTERDAM - Med Int) ; Maasstad Ziekenhuis = Maasstad Hospital | Alzheimercentre, department of Neurology, VU University Medical Center ; Alzheimercentre, department of Neurology, VU University Medical Center | Nuffield Department of Population Health [Oxford] ; University of Oxford | Max Planck Institute for Demographic Research (MPIDR) ; Max-Planck-Gesellschaft | Albert Einstein College of Medicine [New York] | Beijing Forestry University | Duke University [Durham] | Department of Neurology, Alzheimer Centre, VU Medical Centre, Amsterdam | Hinda and Arthur Marcus Institute for Aging Research,Hebrew SeniorLife | Harvard Medical School [Boston] (HMS) | Broad Institute of MIT & Harvard