TNF blockade contributes to restore lipid oxidation during exercise in children with juvenile idiopathic arthritis
2019
Rochette, Emmanuelle | Bourdier, Pierre | Pereira, Bruno | Doré, E | Birat, A | Ratel, Sébastien | Echaubard, Stéphane | Duché, Pascale | Merlin, Etienne | Centre d'Investigation Clinique [CHU Clermont-Ferrand] (CIC 1405) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Direction de la Recherche Clinique et de l’Innovation [CHU Clermont-Ferrand] (DRCI) ; CHU Clermont-Ferrand-CHU Clermont-Ferrand | Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne) | CHU Estaing [Clermont-Ferrand] ; CHU Clermont-Ferrand | Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P) ; Université Clermont Auvergne (UCA)-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA) ; Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA) | CHU Clermont-Ferrand | Impact de l'Activité Physique sur la Santé (IAPS) ; Université de Toulon (UTLN) | Unité de Nutrition Humaine (UNH) ; Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])
International audience
اظهر المزيد [+] اقل [-]إنجليزي. Background Children with juvenile idiopathic arthritis (JIA) have impaired physical abilities. TNF-α plays a crucial role in this pathogenesis, but it is also involved in the use of lipids and muscle health. Objective of this study was to explore substrate oxidation and impact of TNF blockade on energy metabolism in children with JIA as compared to healthy children. Methods Fifteen non-TNF-blockaded and 15 TNF-blockaded children with JIA and 15 healthy controls were matched by sex, age, and Tanner stage. Participants completed a submaximal incremental exercise test on ergocycle to determine fat and carbohydrate oxidation rates by indirect calorimetry. Results The maximal fat oxidation rate during exercise was lower in JIA children untreated by TNF blockade (134.3 ± 45.2 mg.min− 1) when compared to the controls (225.3 ± 92.9 mg.min− 1, p = 0.007); but was higher in JIA children under TNF blockade (163.2 ± 59.0 mg.min− 1, p = 0.31) when compared to JIA children untreated by TNF blockade. At the same relative exercise intensities, there was no difference in carbohydrate oxidation rate between three groups. Conclusions Lipid metabolism during exercise was found to be impaired in children with JIA. However, TNF treatment seems to improve the fat oxidation rate in this population.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institut national de la recherche agronomique
