An overview of the therapeutic effects of leucine supplementation on skeletal muscle under atrophic conditions
2011
Nicastro, Humberto, H. | Artioli, Guilherme Giannini, G. G. | Costa, Andre dos Santos, A. D. S. | Solis, Marina Yazigi, M. Y. | da Luz, Claudia Ribeiro, C. R. | Blachier, Francois, F. | Lancha, Antonio Herbert, A. H. | Sch Phys Educ & Sports, Lab Appl Nutr & Metab ; Universidade de São Paulo = University of São Paulo (USP) | Physiologie de la Nutrition et du Comportement Alimentaire (PNCA) ; Institut National de la Recherche Agronomique (INRA)-AgroParisTech | Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [2008/51090-1, 2009/02896-6]
The characterization of the mechanisms underlying skeletal muscle atrophy under different conditions has been a constant focus of research. Among anti-atrophic therapies, amino acid supplementation, particularly with leucine, has received a lot of attention. Supplementation has been shown to have remarkable effects on muscle remodeling through protein turnover modulation. This may then impact physiological parameters related to muscle function, and even quality of life. In light of this, leucine supplementation could be a useful therapy for mitigating the atrophic effects of catabolic conditions. The purpose of this review is to present the major results of human studies evaluating the effects of leucine supplementation on structure and function of skeletal muscle in atrophic conditions such as muscle disuse, sarcopenia, and cancer.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
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