Evidence for circulation of Rift Valley fever virus in wildlife and domestic animals in a forest environment in Gabon, Central Africa
2024
Becquart, Pierre | Bohou Kombila, Linda | Ndong Mebaley, Telstar | Paupy, Christophe | Garcia, Déborah | Nesi, Nicolas | Olive, Marie-Marie | Vanhomwegen, Jessica | Boundenga, Larson | Mombo, Illich Manfred | Piro-Mégy, Camille | Fritz, Matthieu | Lenguiya, Léadisaelle Hosanna | Ar Gouilh, Meriadeg | Leroy, Eric, M. | N’dilimabaka, Nadine | Cêtre-Sossah, Catherine | Maganga, Gael Darren | Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC) ; Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [Occitanie])-Université de Montpellier (UM) | Centre International de Recherches Médicales de Franceville (CIRMF) | Dynamique Microbienne associée aux Infections Urinaires et Respiratoires (DYNAMICURE) ; Université de Caen Normandie (UNICAEN) ; Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN) ; Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM) | CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie (CHU Caen Normandie) ; Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN) | Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Cellule d'Intervention Biologique d'Urgence (Centre National de Référence) - Laboratory for Urgent Response to Biological Threats (National Reference Center) (CIBU) ; Université Paris Cité (UPCité)-Environnement et Risques infectieux - Environment and Infectious Risks (ERI) ; Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité)-Institut Pasteur [Paris] (IP) | Department of Anthropology [Durham University] ; Durham University | Université Marien-Ngouabi [Université de Brazzaville] = Marien Ngouabi University [University of Brazzaville] (UMNG) | Université des Sciences et Techniques de Masuku (USTM) | E.M.L. received a funding by the World Organization for Animal Health (WOAH) through the European Union (EBO-SURSY: FOOD/2016/379-660: Capacity building and surveillance for Ebola virus disease) for this study.
International audience
اظهر المزيد [+] اقل [-]إنجليزي. Rift Valley fever (RVF) is a mosquito-borne viral zoonosis caused by the Rift Valley fever virus (RVFV) that can infect domestic and wild animals. Although the RVFV transmission cycle has been well documented across Africa in savanna ecosystems, little is known about its transmission in tropical rainforest settings, particularly in Central Africa. We therefore conducted a survey in northeastern Gabon to assess RVFV circulation among wild and domestic animals. Among 163 wildlife samples tested using RVFV-specific RT-qPCR, four ruminants belonging to subfamily Cephalophinae were detected positive. The phylogenetic analysis revealed that the four RVFV sequences clustered together with a virus isolated in Namibia within the well-structured Egyptian clade. A cross-sectional survey conducted on sheep, goats and dogs living in villages within the same area determined the IgG RVFV-specific antibody prevalence using cELISA. Out of the 306 small ruminants tested (214 goats, 92 sheep), an overall antibody prevalence of 15.4% (95% CI [11.5–19.9]) was observed with a higher rate in goats than in sheep (20.1% versus 3.3%). RVFV-specific antibodies were detected in a single dog out of the 26 tested. Neither age, sex of domestic animals nor season was found to be significant risk factors of RVFV occurrence. Our findings highlight sylvatic circulation of RVFV for the first time in Gabon. These results stress the need to develop adequate surveillance plan measures to better control the public health threat of RVFV.
اظهر المزيد [+] اقل [-]المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institut national de la recherche agronomique