Human health risks related to the consumption of foodstuffs of animal origin contaminated by bisphenol A
2017
Gorecki, Sébastien | Bemrah, Nawel | Roudot, Alain-Claude | Marchioni, Eric | Le Bizec, Bruno | Faivre, Franck | Kadawathagedara, Manik | Botton, Jérémie | Rivière, Gilles | Eden Mother-Child Cohort Study Group, . | Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES) | Université de Brest (UBO) | Université de Strasbourg (UNISTRA) | Laboratoire d'étude des Résidus et Contaminants dans les Aliments (LABERCA) ; Institut National de la Recherche Agronomique (INRA)-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS) | LUNAM Université [Nantes Angers Le Mans] | Ministère de l'Agriculture et de l'Alimentation | Service de biostatistique et information médicale de l’hôpital Saint Louis (Equipe ECSTRA) (SBIM) ; Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut national du cancer (INCa)-Hopital Saint-Louis [AP-HP] (AP-HP) ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) | Faculty of pharmacy ; Université Paris-Sud - Paris 11 (UP11) | Institut National de la Santé et de la Recherche Médicale (INSERM) | Foundation for medical research (FRM) ; National Agency for Research (ANR) [ANR-06-BLAN-0359] ; National Institute for Research in Public health (IRESP: TGIR cohorte santé 2008 program) ; French Ministry of Health (DGS) ; French Ministry of Research ; INSERM Bone and Joint Diseases National Research (PRO-A) and Human Nutrition National Research Programs ; Paris-Sud University ; Nestlé ; French National Institute for Population Health Surveillance (InVS) ; French National Institute for Health Education (INPES) ; European Union FP7 programme (HELIX project) ; European Union FP7 programme (ESCAPE project) ; European Union FP7 programme (ENRIECO project) ; Diabetes National Research Program through a collaboration with the French Association of Diabetic Patients (AFD) ; French Agency for Environmental Health Safety ; Mutuelle Générale de l'Education Nationale a complementary health insurance (MGEN) ; French national agency for food security ; French speaking association for the study of diabetes and metabolism (ALFEDIAM) | ANR-06-BLAN-0359,EDEN,Etude des déterminants pré et post natals précoces de la santé et de développement de l'enfant(2006) | European Project: 261357,FP7-HEALTH-2010-single-stage,FP7-HEALTH-2010-single-stage,MEDALL(2010)
International audience
اظهر المزيد [+] اقل [-]إنجليزي. Bisphenol A (BPA) is used in a wide variety of products and objects for consumers use (digital media such as CD's and DVD's, sport equipment, food and beverage containers, medical equipment). For humans, the main route of exposure to BPA is food. Based on previous estimates, almost 20% of the dietary exposure to BPA in the French population would be from food of animal origin. However, due to the use of composite samples, the source of the contamination had not been identified. Therefore, 322 individual samples of non-canned foods of animal origin were collected with the objectives of first updating the estimation of the exposure of the French population and second identifying the source of contamination of these foodstuffs using a specific analytical method. Compared to previous estimates in France, a decline in the contamination of the samples was observed, in particular with regard to meat. The estimated mean dietary exposures ranged from 0.048 to 0.050 μg (kg bw)(-1) d(-1) for 3-17 year children and adolescents, from 0.034 to 0.035 μg (kg bw)(-1) d(-1) for adults and from 0.047 to 0.049 μg (kg bw)(-1) d(-1) for pregnant women. The contribution of meat to total dietary exposure of pregnant women, adults and children was up to three times lower than the previous estimates. Despite this downward trend in contamination, the toxicological values were observed to have been exceeded for the population of pregnant women. With the aim of acquiring more knowledge about the origin the potential source(s) of contamination of non-canned foods of animal origin, a specific analytical method was developed to directly identify and quantify the presence of conjugated BPA (BPA-monoglucuronide, BPA-diglucuronide and sulphate forms) in 50 samples. No conjugated forms of BPAs were detected in the analysed samples, indicating clearly that BPA content in animal food was not due to metabolism but arise <em>post mortem</em> in food. This contamination may occur during food production. However, despite extensive sampling performed in several different shops (butcheries, supermarkets ....) and in different conditions (fresh, prepared, frozen ...), the source(s) of the contamination could not be specifically identified.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institut national de la recherche agronomique