The immune response of ruminant livestock to bluetongue virus:From type I interferon to antibody
2014
Maclachlana, N. James | Henderson, Christine | Schwartz-Cornil, Isabelle | Zientara, Stéphan | Department of Pathology Microbiology and Immunology, ; University of California (UC) | Merial Inc. | Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)) ; Institut National de la Recherche Agronomique (INRA) | Virologie UMR1161 (VIRO) ; École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES) | Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES) | École nationale vétérinaire d'Alfort (ENVA) | USDA NRI Competitive Grant [2002-35204-12314]; Harriet E. Pfleger Foundation
hal-01190011
اظهر المزيد [+] اقل [-]إنجليزي. Infection of ruminants with most (but not all) serotypes of bluetongue virus (BTV) leads to a highly bloodcell-associated viremia that may be prolonged but not persistent. Furthermore, recovered animals areresistant to reinfection with the homologous virus serotype, which is the basis for vaccination strategiesto prevent BTV infection and the clinical disease (bluetongue) that it causes in domestic livestock. BTVinfection is initiated at the site of virus inoculation and the associated draining lymph node, from wherethe virus is then spread in lymph cells to the systemic circulation and secondary sites of replication.Replication of BTV in target cells, notably mononuclear phagocytic cells (dendritic cells and macrophages)and endothelium, leads to the generation of the innate and adaptive immune responses that mediate bothinitial virus clearance and subsequent resistance to infection with the homologous virus serotype. Thegoal of this review is to summarize current understanding of these innate and adaptive immune responsesof animals to BTV infection.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institut national de la recherche agronomique