Palatability Can Drive Feeding Independent of AgRP Neurons
2015
Denis, Raphael Georges | Joly-Amado, Aurélie | Webber, Emily | Langlet, Fanny | Schaeffer, Marie | Padilla, Stéphanie | Cansell, Céline | Dehouck, Bénédicte | Castel, Julien | Delbes, Anne-Sophie | Martinez, Sarah | Lacombe, Amélie | Rouch, Claude | Kassis, Nadim | Fehrentz, Jean-Alain | Martinez, Jean | Verdie, Pascal | Hnasko, Thomas S. | Palmiter, Richard D. | Krashes, Michael J. | Güler, Ali D. | Magnan, Christophe | Luquet, Serge | Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité) | National Institute of Diabetes and Digestive and Kidney Diseases [Bethesda] | Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc) ; Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille | Institut de Génomique Fonctionnelle (IGF) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) | University of Washington [Seattle] | Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM) ; Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM) ; Université de Montpellier (UM) | University of California [San Diego] (UC San Diego) ; University of California (UC) | University of Virginia
International audience
اظهر المزيد [+] اقل [-]إنجليزي. Feeding behavior is exquisitely regulated by homeostatic and hedonic neural substrates that integrate energy demand as well as the reinforcing and rewarding aspects of food. Understanding the net contribution of homeostatic and reward-driven feeding has become critical because of the ubiquitous source of energy-dense foods and the consequent obesity epidemic. Hypothalamic agouti-related peptide-secreting neurons (AgRP neurons) provide the primary orexigenic drive of homeostatic feeding. Using models of neuronal inhibition or ablation, we demonstrate that the feeding response to a fast ghrelin or serotonin receptor agonist relies on AgRP neurons. However, when palatable food is provided, AgRP neurons are dispensable for an appropriate feeding response. In addition, AgRP-ablated mice present exacerbated stress-induced anorexia and palatable food intake--a hallmark of comfort feeding. These results suggest that, when AgRP neuron activity is impaired, neural circuits sensitive to emotion and stress are engaged and modulated by food palatability and dopamine signaling.
اظهر المزيد [+] اقل [-]المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institut national de la recherche agronomique
