Growth factor based therapies and intestinal disease: Is glucagon-like peptide-2 the new way forward?
2009
Yazbek, R. | Howarth, G. | Abbott, C.
Copyright © 2009 Published by Elsevier Ltd.
اظهر المزيد [+] اقل [-]Inflammatory bowel disease (IBD) is a chronic, debilitating disease associated with severe damage to the intestinal mucosa. Glucagon-like peptide-2 (GLP-2) is a potent and specific gastrointestinal growth factor that is demonstrating therapeutic potential for the prevention or treatment of an expanding number of intestinal diseases, including short bowel syndrome (SBS), small bowel enteritis and IBD. The biological activity of GLP-2 is limited due to proteolytic inactivation by the protease dipeptidyl peptidase (DP)IV. Inhibitors of DPIV activity may represent a novel strategy to prolong the growth promoting actions of GLP-2. This review outlines evidence for the clinical application of GLP-2, its degradation resistant analogue, Teduglutide, and novel DPIV inhibitors in efficacy studies utilizing pre-clinical models of intestinal damage, in particular IBD.
اظهر المزيد [+] اقل [-]Roger Yazbeck, Gordon S. Howarth and Catherine A. Abbott
اظهر المزيد [+] اقل [-]http://www.elsevier.com/wps/find/journaldescription.cws_home/868/description#description
اظهر المزيد [+] اقل [-]المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل University of Adelaide