H3K4me3 - dependent epigenetic memory regulates transcriptional reactivation in the oocyte
2015
Navarro-Costa, P. | Prudêncio, P. | J.D., Becker | R.G., Martinho
SELECTED ORAL COMMUNICATIONS, SESSION 52: EPIGENETIC PATTERN IN OOCYTE AND EMBRYO, Tuesday 16 June 2015. This article/study appears in: Abstract book of the 31st ESHRE Annual Meeting, Lisbon, Portugal, 14-17 June 2015.
اظهر المزيد [+] اقل [-]Study question: How does the oocyte regulate its transcriptional activity in light of its prolonged meiotic arrest? Summary answer: A histone methylation-mediated epigenetic memory programed by the demethylase KDM5 is required for the correct temporal reactivation of the oocyte's transcriptional activity. What is known already: During oogenesis oocytes transit from stages of transcriptional activity to those of transcriptional quiescence, and such transitions are believed to be essential for proper gamete formation. Although the temporal regulation of these transitions has been well documented across diverse organisms, the molecular mechanisms underlying these processes remain largely unknown.
اظهر المزيد [+] اقل [-]Funding by national/international organization(s) – Partly funded by Fundação para a Ciência e a Tecnologia.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Fundação Calouste Gulbenkian