The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives

d'Enfert, Christophe | Kaune, Ann-Kristin | Alaban, Leovigildo-Rey | Chakraborty, Sayoni | Cole, Nathaniel | Delavy, Margot | Kosmala, Daria | Marsaux, Benoît | Fróis-Martins, Ricardo | Morelli, Moran | Rosati, Diletta | Valentine, Marisa | Xie, Zixuan | Emritloll, Yoan | Warn, Peter | Bequet, Frédéric | Bougnoux, Marie-Elisabeth | Bornes, Stéphanie | Gresnigt, Mark | Hube, Bernhard | Jacobsen, Ilse | Legrand, Mélanie | Leibundgut-Landmann, Salomé | Manichanh, Chaysavanh | Munro, Carol | Netea, Mihai | Queiroz, Karla | Roget, Karine | Thomas, Vincent | Thoral, Claudia | Van den abbeele, Pieter | Walker, Alan | Brown, Alistair | Biologie et Pathogénicité fongiques - Fungal Biology and Pathogenicity (BPF) ; Institut Pasteur [Paris] (IP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | University of Aberdeen | BIOASTER Microbiology Technology Institute [Lyon] | École Doctorale Bio Sorbonne Paris Cité [Paris] (ED562 - BioSPC) ; Université Sorbonne Paris Cité (USPC)-Université Paris Cité (UPCité) | Leibniz Institute for Natural Product Research and Infection Biology (Hans Knoell Institute) | Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany] | ProDigest BVBA ; Partenaires INRAE | Universiteit Gent = Ghent University = Université de Gand (UGENT) | Universität Zürich [Zürich] = University of Zurich (UZH) | Mimetas | Radboud University Medical Center [Nijmegen] (RadboudUMC) | Vall d'Hebron University Hospital [Barcelona] | Magic Bullet Consulting | Unité Mixte de Recherche sur le Fromage (UMRF) ; VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA) | Nexbiome Therapeutics [Clermont-Ferrand] | University of Exeter | We received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie action, Innovative Training Network: FunHoMic; grant N° 812969. CdE received funding from the French Government ‘Investissement d'Avenir’ program (Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases, ANR-10-LABX-62-IBEID), the Agence Nationale de la Recherche (ERA-Net Infect-ERA, FUNCOMPATH, ANR-14-IFEC-0004), the EU Horizon2020 consortium ‘Host-Directed Medicine in invasive FUNgal infections’—HDM-FUN (Grant Agreement 847507). SLL and CdE received funding from the Swiss National Science Foundation (Sinergia program, #CRSII5_173863). BIOASTER received funding from the French Government ‘Investissement d'Avenir’ program (Grant No. ANR-10-AIRT-03). MSG was supported by a Humboldt Research Fellowship for Postdoctoral Researchers by the Alexander von Humboldt-Foundation and the Deutsche Forschungsgemeinschaft (DFG) Emmy Noether Program (project no. 434385622/GR 5617/1-1). BH was supported by the Deutsche Forschungsgemeinschaft (DFG) project Hu 532/20-1, project C1 within the Collaborative Research Centre (CRC)/Transregio 124 FungiNet and the Balance of the Microverse Cluster under Germany´s Excellence Strategy—EXC 2051–Project-ID 390713860, the EU Horizon2020 consortium ‘Host-Directed Medicine in invasive FUNgal infections’—HDM-FUN (Grant Agreement 847507), the Leibniz Association Campus InfectoOptics SAS-2015-HKI-LWC and the Wellcome Trust (215599/Z/19/Z). IDJ was supported by the Deutsche Forschungsgemeinschaft (DFG) project C5 within the Collaborative Research Centre (CRC)/Transregio 124 FungiNet and the Balance of the Microverse Cluster under Germany´s Excellence Strategy—EXC 2051–Project-ID 390713860, the Leibniz Association Campus InfectoOptics SAS-2015-HKI-LWC and the Wellcome Trust (Grant 215599/Z/19/Z). CM received funding from the the Instituto de Salud Carlos III/FEDER. MGN was supported by an ERC Advanced Grant (#833247) and a Spinoza grant of the Netherlands Organization for Scientific Research. CAM was supported by EU Horizon2020 consortium ‘Host-Directed Medicine in invasive FUNgal infections’—HDM-FUN (Grant Agreement 847507) and the Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology (097377/Z/11/Z). AWW receives core funding support from the Scottish Government's Rural and Environment Science and Analytical Services (RESAS). AJPB was supported by a programme grant from the UK Medical Research Council (MR/M026663/1) and by the Medical Research Council Centre for Medical Mycology at the University of Exeter (MR/N006364/1). | ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010) | ANR-14-IFEC-0004,FunComPath,From fungal commensalism to pathogenicity:dissection of the colonization-to-infection shift of Candida albicans(2014) | ANR-10-AIRT-0003,BIOASTER,BIOASTER(2010) | European Project: 812969,H2020-MSCA-ITN-2018,FunHoMic(2019) | European Project: 847507,H2020-SC1-2019-Two-Stage-RTD,HDM-FUN(2020)