Proposal for a unified nomenclature for target-site mutations associated with resistance to fungicides
2016
Mair, Wesley | Lopez-Ruiz, Francisco | Stammler, Gerd | Clark, William | Burnett, Fiona | Hollomon, Derek | Ishii, Hideo | Thind, Tarlochan S | Brown, James Km | Fraaije, Bart | Cools, Hans | Shaw, Michael | Fillinger, Sabine | Walker, Anne-Sophie | Mellado, Emilia | Schnabel, Guido | Mehl, Andreas | Oliver, Richard P | Dept.Environm & Agri. Ctr Crop Dis Management ; Curtin University | Dept Environm & Agr;Ctr Crop Dis Management ; Curtin University | Ctr Agr, Fungicide Resistance Res. ; BASF SE | National Institute of Agricultural Botany (NIAB) | Scotland's Rural College (SRUC) | Orchard house | Sch Agr Reg Vitalisat ; Kibi Int Univ | Punjab Agricultural University (PAU) | John Innes Centre [Norwich] ; Biotechnology and Biological Sciences Research Council (BBSRC) | Rothamsted Research ; Biotechnology and Biological Sciences Research Council (BBSRC) | Jealott's Hill International Research Centre, Bracknell ; Syngenta Ltd | University of Reading (UOR) | BIOlogie et GEstion des Risques en agriculture (BIOGER) ; Institut National de la Recherche Agronomique (INRA)-AgroParisTech | Centro National de Microbiologia ; Instituto de Salud Carlos III [Madrid] (ISCIII) | Department of Agricultural and Environmental Sciences ; Clemson University | Research Disease Control ; Bayer AG [Germany] | Centre for Crop Disease Management, Department of Environment and Agriculture ; Curtin University
online
اظهر المزيد [+] اقل [-]إنجليزي. Evolved resistance to fungicides is a major problem limiting our ability to control agricultural, medical and veterinary pathogens and is frequently associated with substitutions in the amino acid sequence of the target protein. The convention for describing amino acid substitutions is to cite the wild-type amino acid, the codon number and the new amino acid, using the one-letter amino acid code. It has frequently been observed that orthologous amino acid mutations have been selected in different species by fungicides from the same mode of action class, but the amino acids have different numbers. These differences in numbering arise from the different lengths of the proteins in each species. The purpose of the present paper is to propose a system for unifying the labelling of amino acids in fungicide target proteins. To do this we have produced alignments between fungicide target proteins of relevant species fitted to a well-studied archetype' species. Orthologous amino acids in all species are then assigned numerical labels' based on the position of the amino acid in the archetype protein. (c) 2016 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institut national de la recherche agronomique