Genomic Characterization of a Relative of Mumps Virus in Lesser Dawn Bats of Southeast Asia
2023
Adrian C. Paskey | Xiao Fang Lim | Justin H. J. Ng | Gregory K. Rice | Wan Ni Chia | Casandra W. Philipson | Randy Foo | Regina Z. Cer | Kyle A. Long | Matthew R. Lueder | Lindsay Glang | Kenneth G. Frey | Theron Hamilton | Ian H. Mendenhall | Gavin J. Smith | Danielle E. Anderson | Lin-Fa Wang | Kimberly A. Bishop-Lilly
The importance of genomic surveillance on emerging diseases continues to be highlighted with the ongoing SARS-CoV-2 pandemic. Here, we present an analysis of a new bat-borne mumps virus (MuV) in a captive colony of lesser dawn bats (<i>Eonycteris spelaea</i>). This report describes an investigation of MuV-specific data originally collected as part of a longitudinal virome study of apparently healthy, captive lesser dawn bats in Southeast Asia (BioProject ID PRJNA561193) which was the first report of a MuV-like virus, named dawn bat paramyxovirus (DbPV), in bats outside of Africa. More in-depth analysis of these original RNA sequences in the current report reveals that the new DbPV genome shares only 86% amino acid identity with the RNA-dependent RNA polymerase of its closest relative, the African bat-borne mumps virus (AbMuV). While there is no obvious immediate cause for concern, it is important to continue investigating and monitoring bat-borne MuVs to determine the risk of human infection.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
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