Effect of glycerol on properties of chitosan/chlorhexidine membranes and antibacterial activity against Streptococcus mutans
2024
José Alberto Hachity-Ortega | José Alberto Hachity-Ortega | Alberto V. Jerezano-Domínguez | Laura Abisai Pazos-Rojas | Laura Abisai Pazos-Rojas | Abigailt Flores-Ledesma | Diana del C. Pazos-Guarneros | Karla Aimée Parra-Solar | Eric Reyes-Cervantes | Ismael Juárez-Díaz | Manuel E. Medina | Mayra González-Martínez | Brenda Eréndida Castillo-Silva | Beatriz Xochitl Ávila-Curiel | Jesús Hernández-Juárez | América Rivera-Urbalejo | América Rivera-Urbalejo | Paola G. Gordillo-Guerra | Miguel Angel Casillas-Santana
IntroductionChitosan membranes with glycerol can function as an effective dispersing agent for different antibiotics or active ingredients that can be used in the treatment of diseases present in the oral cavity.MethodsThe effects of the addition of glycerol on the mechanical, water absorption, swelling, pH, thickness, disintegration, rugosity, and antibacterial properties of chitosan-chlorhexidine- glycerol membranes were investigated in this study.Results and discussionMechanical results indicated that chitosan membranes' rugosity, strength, flexion, and thickness differed at loading 1, 3, 5, 10, 15, and 20% of glycerol (p < 0.05). The chitosan membranes' rugosity, dissolution, strength, and pH results were significantly enhanced by the presence of glycerol at 3, 5, and 10% concentrations. In this investigation, the antimicrobial activity model used was the inhibition of Streptococcus mutans CDBB-B-1455 by chitosan-chlorhexidine membranes. It was observed that there was no change in inhibition with different concentrations of glycerol. The results suggest that chitosan-glycerol-chlorhexidine membranes may be a potential candidate for topical antiseptic application in buccal-dental disorders caused by S. mutans, such as caries, periodontal diseases, and oral squamous cell carcinoma, helping to prevent the development of serious conditions that can compromise human health.
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