Comparative study of anti-measles immunity in adult population of Sochi and laboratory primates of Adler primate center
2019
L. I. Korzaya | D. I. Dogadov | A. M. Goncharenko | B. A. Lapin
Aim. Comparative study of the level of anti-measles immunity in monkeys of the Primate Center , colony service staff and in some groups of the population of the Adler region. Materials and methods. In this study 1077 sera have been investigated : 354-from humans and 723-from monkeys. Commercial test systems were used to determine IgG and IgM antibodies to measles virus by IEA (immune enzyme analysis). Results. An extremely low degree of anti-measles immunity among monkeys of different species of the Adler Primate Center (10,2±1,4%) at the expense of the individuals born before 1993 was revealed. In cynomolgus monkeys (Macaca fascicularis) imported from Vietnam and the Republic of Mauritius in 2015-2017 the rate of detection of anti-IgG varied from 2.3% to 57.5%. Anti-IgM was no detected. The rate of anti — measles immunity in the adult population was generally below normal (86.4±1.8%), but varied in different groups (57.8-100%). A significant difference was found (p≤0.05) not only in the percentage of individuals with the immunity to measles virus among persons aged 18-35 compared with persons aged 36-75 years (73.6±3.5% and 96.9±1.2%, respectively), but also in the average antibody titers (1.34±0.26 IU/ml and 2.92±0.24 IU/ml, respectively). The lowest percentage of seropositive individuals (57.8±6.2%) and antibody levels (0.97±0.21 IU/ml) were observed in a group of students (18-25 years old). Conclusion. The presence of individuals (26.4%) seronegative to the measles virus among young people aged 18-35 years supports the necessity of vaccination against measles. The emergence of a source of infection among nonimmune monkeys (89.8%) born after 1992 may lead to an outbreak of measles.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Directory of Open Access Journals