Understanding the Inflammatory Biomarkers in Patients with Acrochordons: A Case-control Study
2021
Kinjal Prahaladbhai Patel | Haridas Neelakandan Nilayangode | Pragya Ashok Nair
Introduction: Acrochordons {Skin Tags (ST)} are common benign skin tumours usually occurring on the neck and major flexors of older and obese people. A few studies with conflicting results have been reported regarding the abnormalities of carbohydrate or lipid metabolisms, and the involvement of some inflammatory markers in patients with acrochordons. Aim: Comparisons of Fasting Blood Sugar (FBS), lipid profile, andC-Reactive Protein (CRP) between patients of acrochordon, and healthy controls. Materials and Methods: The present case control study was conducted in the Department of Biochemistry and Dermatology of Pramukhswami Medical College, Karamsad, Gujarat. A total number of 160 subjects (80 healthy controls and 80 cases with acrochordons) were included. FBS, Lipid Profile, and CRP were measured. Statistical analysis was performed by independent t-test, On-way Anova, Frequency, Descriptive Statistics, Pearson’s correlation coefficient (r). Results: Basal Metabolic Index (BMI), FBS, Lipid profile and CRP were measured. There were significant differences between mean of various parameters (p<0.001) for cases compare to controls.There were significant correlations between all parameters of two groups in the aspect of various size, colour, and number of acrochordons (p<0.001). Conclusion: Threat of progress of metabolic syndrome is significantly higher in patients with Acrochordons. Among the many elements of inflammations and metabolic syndrome, BMI, CRP, lipid profile and plasma sugar are remarkably linked with Acrochordons.
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