Evaluation of Eosinophilic Cationic Protein and Some Immunological Markers in Patients Infected with Scabies

The current study is trying to identify some effects of scabies on some vital indicators such as (ECP, IgE, MCP-1 and IL-17). The results showed that levels of ECP has significant increase (P<0.05 (9569.3 ±256.10 pg /ml), (9872.9± 260.50) respectively in comparison with the control group (7665.2 ± 385.72 pg /ml), (7834.1± 251.43 pg /ml) respectively, The result proved that there was the significant increase (P (9721.1 ±181.15 pg /ml), (7749.7± 226.75) respectively in concentration of (ECP) in patients with S. scabiei and total healthy individuals. The levels of IgE had significant increase (P (284.8 ±34.05 IU /ml), (249.85± 13.682 IU /ml) respectively in comparison with the control group (119.5 ± 11.24 IU /ml), (108.77± 8.3 IU /ml) respectively. The result indicate that there was significant increase (P (267.134 ±18. 334 IU /ml), (114.13± 6.94 IU /ml) respectively in concentration of (IgE) in total patients infected with S. scabiei and total control group. The levels of MCP-1 has significant increase (P (271.76 ±29. 88 pg /ml), (246.983± 27.57 pg /ml) respectively in comparison with the control group (153. 27 ± 21.071pg/ml), (154.67± 22.973 pg /ml) respectively, Also it revealed the significant increase (P (259.29±20. 22 pg /ml), (153. 97± 15.21 pg /ml) respectively in concentration of (MCP-1) in S. scabiei patients and total healthy individuals. IL-17 had significant increase (P (16.318 ±0. 71 pg /ml), (16.847± 0.58 pg /ml) respectively in comparison with the control group (5. 6009 ±0. 45 pg/ml), (5.2023± 0. 35 pg /ml) respectively. The current study shows that there was significant increase (P (16.583±0. 45pg /ml), (16.4016± 0.28 pg /ml) respectively in concentration of (IL-17) in total patients infected with S. scabiei and total healthy individuals. The levels of IL-2 had significant increase (P (21.14 ±0. 8081 pg /ml), (21.800± 1.0644 pg /ml) respectively in comparison with total healthy individuals (7. 447 ±0. 2422 pg/ml), (7.7235± 0. 1716 pg /ml) respectively, Also it revealed the significant increase (P (20.972±0. 6626pg /ml), (7.5853± 0.1480 pg /ml) respectively in concentration of (IL-2) in total patients infected with S. scabiei and total control group. Conclusions: the results indicate that infection of scabies influences on the human immunity represented by the ECP, IgE MCP-1 and IL-17 in patients infected with scabies and may be used as good biomarkers in detection of scabies.