Roles of rutin in cardiac remodeling
2020
Hawa Nordin Siti | Juriyati Jalil | Ahmad Yusof Asmadi | Yusof Kamisah
Rutin has been demonstrated to possess potential cardioprotective effects in cardiac remodeling. Thus, the purpose of this review is to present gathered information on the roles of rutin in cardiac remodeling, which has gained attention as a therapeutic target in cardiac pathology, particularly heart failure. Such studies are focusing more on secondary manifestations and primary endpoints of cardiac dysfunction, rather than targeting cellular and molecular mechanisms that are responsible for cardiac disease progression. Recent scientific evidence has revealed the effects of rutin on molecular and cellular changes in cardiac remodeling pathogenesis. Conclusively, rutin shows beneficial effects on cardiac remodeling, evidenced by its effects on cardiac structure and function in several cardiac disease models via multiple pathways. Understanding its current roles in cardiac remodeling, helps in terms of further research on rutin be designed for its development as a potential therapy in cardiac remodeling, and then heart failure.
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