Nutritional profile of High Fat Simple Carbohydrate Diet used to induce metabolic syndrome in C57BL/6J mice
2016
Serena Stephen D'Souza | B. Sri Charan Bindu | M. Mohammed Ali | Alex Tisha | K.V. Deepthi | Silveira Siona | Fernandes Santy | Asha Abraham
Purpose: Many diet based studies on metabolic syndrome lack an in-depth study of feed nutrient profile post preparation. We analyzed the nutritional profile of formulated High Fat Simple Carbohydrate (HFSC) feed and studied its effect on target organs. Methods: Control feed and HFSC feed were analyzed for macro and micronutrient profile and fed to one month male C57BL/6J mice for 5 months during which feed intake, energy intake and feed efficiency was monitored. The effects of feeds were preliminarily studied on kidney, liver, adrenal gland and pancreas by histological staining. Results: The HFSC feed had significantly lower carbohydrate, moisture, crude fiber, ash content, mineral, vitamin content, higher ω-6/ω-3 fatty acid ratio as compared to control feed. The HFSC fed mice had higher food intake; energy intake; feed efficiency; lymphocyte infiltration in the liver; hypertrophy of the kidney, adrenal medulla and degenerated islets of pancreas as compared to the control mice after 5 months of feeding. Conclusion: Food with a higher ω-6/ω-3 fatty acid ratio and simple carbohydrate leads to deterioration of structural integrity of vital organs.
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