Antiglycation Effect of Jabuticaba (<i>Plinia cauliflora</i>) and Its Potential Role in Delaying Cataract Formation in Streptozotocin-Induced Diabetic Rats
2024
Arif Yanuar Ridwan | Yuki Shimozu | Nikesh Narang | Takashi Kometani | Yusuke Yamashita | Young-Il Kim
Jabuticaba fruit (<i>Plinia cauliflora</i>) is widely consumed in various forms such as juice, jam, wine, and liquors; however, its potential therapeutic effects on diabetic complications remain inadequately explored. We aimed to investigate the potential antiglycation activity of Jabuticaba, identify the active compounds through bioassay-guided fractionation, and assess its effects on cataract formation in a Streptozotocin-induced diabetic type 1 rat model. Through bioassay-guided fractionation, we identified gallic acid (IC<sub>50</sub>: 24.7 µg/mL), protocatechuic acid (IC<sub>50</sub>: 1.22 µg/mL), and an ellagitannin, Repandinin B (IC<sub>50</sub>: 0.55 µg/mL), as active compounds contributing to antiglycation effects. In the animal study, the addition of Jabuticaba juice extract to the drinking water at a concentration of 0.5% (<i>w</i>/<i>v</i>) for 12 weeks demonstrated an amelioration in cataract progression. These results suggest that Jabuticaba has high antiglycation effects leading to the delaying of cataract formation in type 1 diabetes.
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